Role of MYC in the tumor microenvironment in high grade non-Hodgkin B cell lymphomas

Murti, Krisna and Muslina, Muslina and Nursanti, Apriyani and Hafy, Zen (2023) Role of MYC in the tumor microenvironment in high grade non-Hodgkin B cell lymphomas. Journal of Physics: Conference Series, 1246. pp. 1-6. ISSN 1742-6588

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Abstract

High-grade non-Hodgkin's B cells lymphomas (NHLs) are malignant tumours of the lymphoid system. MYC protein was known correlated with poor prognosis. In addition to promoting cell-cycle progression, MYC plays an important role activation of an alternative pathway of a tumour associated macrophage (TAM). We further determined if MYC protein expression correlated with the high density of TAM. This was a cross-sectional study of 47 specimens of high-grade non-Hodgkin B cell lymphomas. Their immunophenotype was reevaluated, and stratified into DLBCL and others non-Hodgkin lymphomas. All samples were immunostained with MYC and CD163 antibodies. The expression of MYC and CD163 were scored according to the previous study. Statistical analysis was performed by using SPSS version 22. MYC positive expression was detected in 72,3% of patients. Its found mostly in male patient, age ≤60, and Ki67 >70%. Average density of TAMs was 7,29. An average density of TAM in MYC positive lymphomas was higher rather than MYC negative lymphomas. MYC may facilitate the high density of TAM and contribute to worst prognosis in younger male patient and Ki67 >70%, of high-grade B cell lymphomas.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	04-Faculty of Medicine > 11718-Pathology Anatomy (Sp
Depositing User:	dr., Ph.D. Krisna Murti
Date Deposited:	12 May 2023 16:00
Last Modified:	12 May 2023 16:00
URI:	http://repository.unsri.ac.id/id/eprint/101454

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