Miksusanti, Miksusanti (2020) Optimization of chitosan–tapioca starch composite as polymer in the formulation of gingival mucoadhesive patch film for delivery of gambier (Uncaria gambir Roxb) leaf extract. International Journal of Biological Macromolecules, 144. pp. 289-295.
![[thumbnail of JURNAL SCOPUS Q1 BIOMOLEKUL.pdf]](http://repository.unsri.ac.id/style/images/fileicons/text.png) |
Text
JURNAL SCOPUS Q1 BIOMOLEKUL.pdf Download (182kB) |
Abstract
The present study was intended to prepare and optimize the mucoadhesive buccal patch of gambier leaf extract using chitosan (CH) and tapioca starch (TS) composite as the polymer complexes. The patch formulation was designed based on 22 factorial design in order to optimize the composition of CH and TS. The physical and chemical characteristics of the prepared patches, including mass and thickness uniformity, folding endurance, surface pH, swelling index, percent of elongation, and mucoadhesive time were successfully evaluated. Based on statistical analysis, the optimum concentration of CH and TS was 900 mg and 300 mg, respectively, with desirability percent of 0.968. The characterization of the optimum patch showed that the variability coefficient of the mass and thickness uniformity was 0.4805 ± 0.1887% and 0.9716 ± 1.2026%, surface pH of the patch was 6, folding endurance >300 times, elongation percent was 53.333 ± 0.1082%, and mucoadhesive time was 320 ± 1.1547 min. The catechin content, as the active agent of the gambier leaf extract, was 92.1667 ± 0.3626%, and the FT-IR characterization indicated that there are no chemical interactions between each patch component.
| Item Type: | Article |
|---|---|
| Subjects: | #3 Repository of Lecturer Academic Credit Systems (TPAK) > Articles Access for TPAK (Not Open Sources) |
| Divisions: | 08-Faculty of Mathematics and Natural Science > 47201-Chemistry (S1) |
| Depositing User: | Miksusanti Miksusanti |
| Date Deposited: | 21 May 2023 12:12 |
| Last Modified: | 21 May 2023 12:12 |
| URI: | http://repository.unsri.ac.id/id/eprint/104318 |
Actions (login required)
 |
View Item |