OPTIMASI FORMULA SELF-NANOEMULSIFYING (SNE) EKSTRAK KULIT BUAH KOPI DENGAN METODE SIMPLEX LATTICE DESIGN

SIMBOLON, ROSUANTI and Shiyan, Shaum (2023) OPTIMASI FORMULA SELF-NANOEMULSIFYING (SNE) EKSTRAK KULIT BUAH KOPI DENGAN METODE SIMPLEX LATTICE DESIGN. Undergraduate thesis, Sriwijaya University.

[thumbnail of RAMA_48201_08061381924123.pdf] Text
RAMA_48201_08061381924123.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (4MB) | Request a copy
[thumbnail of RAMA_48201_08061381924123_TURNITIN.pdf] Text
RAMA_48201_08061381924123_TURNITIN.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (6MB) | Request a copy
[thumbnail of RAMA_48201_08061381924123_0028058601_01_front_ref.pdf] Text
RAMA_48201_08061381924123_0028058601_01_front_ref.pdf - Accepted Version
Available under License Creative Commons Public Domain Dedication.

Download (917kB)
[thumbnail of RAMA_48201_08061381924123_0028058601_02.pdf] Text
RAMA_48201_08061381924123_0028058601_02.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (301kB) | Request a copy
[thumbnail of RAMA_48201_08061381924123_0028058601_03.pdf] Text
RAMA_48201_08061381924123_0028058601_03.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (305kB) | Request a copy
[thumbnail of RAMA_48201_08061381924123_0028058601_04.pdf] Text
RAMA_48201_08061381924123_0028058601_04.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (1MB) | Request a copy
[thumbnail of RAMA_48201_08061381924123_0028058601_05.pdf] Text
RAMA_48201_08061381924123_0028058601_05.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (188kB) | Request a copy
[thumbnail of RAMA_48201_08061381924123_0028058601_06_ref.pdf] Text
RAMA_48201_08061381924123_0028058601_06_ref.pdf - Bibliography
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (266kB) | Request a copy
[thumbnail of RAMA_48201_08061381924123_0028058601_07_lamp.pdf] Text
RAMA_48201_08061381924123_0028058601_07_lamp.pdf - Accepted Version
Restricted to Repository staff only
Available under License Creative Commons Public Domain Dedication.

Download (2MB) | Request a copy

Abstract

The main problem in the coffee processing process is the handling of coffee waste. Coffee fruit skin is only used as animal feed. Even though coffee peel extract has potential as an antioxidant because it contains flavonoids, especially catechins. Coffee pod extract has low solubility and bioavailability, so it is formulated in a self-nanoemulsifying (SNE) form. SNE) is able to increase solubility so that with low doses it can provide a better pharmacological effect. This study aims to optimize the SNE process of coffee pod extract assisted by the simplex lattice design (SLD) combined with PCA-CA chemometric analysis. The components used are oleic acid (oil), Tween 80 (surfactant), and PEG 400 (cosurfactant). Evaluation parameters include emulsification time, % transmittance, viscosity, pH, particle size, zeta potential, mobility and polydispersity index. The optimal SNE formula characteristics produced have a pH range of 5.5-6 and the nanoemulsion has an emulsification time of 40.65 seconds (water medium), 438.95 seconds (SGF medium), 51.35 seconds (SIF medium), % transmittance of water nanoemulsion 98.59%, % transmittance of SGF nanoemulsion 96.07%, % transmittance of SIF nanoemulsion 95.20%, zeta potential value -22.23 m/V, mobility -2.01 Nm cm/Vs , particle size 165 .6 nm, and a PDI value of 0.476. The optimal formula of oleic acid with a concentration of 10%, Tween 80 with a concentration of 61%, and PEG 400 28% fulfills the characteristics of SNE and has a correlation in each formula.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Ekstrak kulit kopi, SNE, simplex lattice design
Subjects: R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions: 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Rosuanti Simbolon
Date Deposited: 25 May 2023 03:02
Last Modified: 25 May 2023 03:02
URI: http://repository.unsri.ac.id/id/eprint/105044

Actions (login required)

View Item View Item