Study on the anti-inflammatory properties of Karamunting (Rhodomyrtustomentosa (Aiton) Hassk.) leaf extracts (ARTIKEL)

Herlina, Herlina (2023) Study on the anti-inflammatory properties of Karamunting (Rhodomyrtustomentosa (Aiton) Hassk.) leaf extracts (ARTIKEL). IOP Conf. Series: Journal of Physics: Conf. Series. pp. 1-9. ISSN 1742-6588E-ISSN:1742-6596

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Abstract

Karamunting (Rhodomyrtustomentosa (Aiton) Hassk.) is one of the most widespread plants in Sumaterawhich areknown to have traditionally used as wound and infection remedy. However, research on anti-inflammatory activity is limited. This study aimedto determine the effect of antiinflammatory of Karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.) leaf extracts using acute rat model (carrageenan-induced rat paw oedema). Sodium diclofenac 4,5 mg.kg-1BW as standard anti-inflammatory drug, n-hexane, ethyl acetate, and ethanol of Karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.) leaf extracts each dose 200 mg.kg-1BW were administered orally to 24 Wistar rats 1 h before induction oedema and compared with a negative control given Na CMC 1%. The mean percentage inhibition of paw volume of rats treated with sodium diclofenac was 64,82%, followed by n-hexane extract with 44,75%, ethyl acetat extract with 56,93%, and ethanol extract with 63,56%. All extract have similar antiinflammatory effect with sodium diclofenac (p>0,05). This result suggest that all Karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.) leaf extracts have antiinflammatory properties comparable withstandard drugs.

Item Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) R Medicine > RS Pharmacy and materia medica > RS189-190 Assay methods. Standardization. Analysis
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Herlina Herlina
Date Deposited:	07 Jun 2023 03:21
Last Modified:	07 Jun 2023 03:21
URI:	http://repository.unsri.ac.id/id/eprint/107605

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