Association of vitamin D with deoxyribonucleic acid (DNA) damage: A systematic review of animal and human studies

Murti, Krisna and Lestari, Mayang Indah and Liberty, Iche Andriyani and Hafy, Zen and Linardi, Violantina and Khoirudin, Muhammad and Umar, Tungki Pratama (2023) Association of vitamin D with deoxyribonucleic acid (DNA) damage: A systematic review of animal and human studies. The Journal Of The Polish Biochemical Society and Of The Polish Academy Of Sciences, 70 (2). pp. 379-387. ISSN 0001-527X

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Abstract

Vitamin D has anti-proliferative, anti-inflammatory, and apoptotic abilities. Vitamin D defciency can induce deoxyribonucleic acid (DNA) damage. The aim of the study was to create a systematic review to analyze the relationship between vitamin D and DNA damage in various populations. PubMed, Scopus, EbscoHost, Google Scholar, and Epistemonikos were used to identify literature regarding the relationship between vitamin D and DNA damage. Assessment of study quality was carried out by three independent reviewers individually. A total of 25 studies were assessed as eligible and included in our study. Twelve studies were conducted in humans consisting of two studies with experimental design and ten studies with observational pattern. Meanwhile, thirteen studies were conducted in animals (in vivo). It is found that the majority of studies demonstrated that vitamin D prevents DNA damage and minimizes the impact of DNA damage that has occurred (p<0.05). However, two studies (8%) did not fnd such an association and one research only found a specifc association in the cord blood, not in maternal blood. Vitamin D has a protective effect against DNA damage. A diet rich in vitamin D and vitamin D supplementation is recommended to prevent DNA damage. Keywords: vitamin D, DNA damage, observational studies, in vivo studies, systematic review

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	04-Faculty of Medicine > 11718-Pathology Anatomy (Sp
Depositing User:	dr., Ph.D. Krisna Murti
Date Deposited:	20 Jun 2023 06:41
Last Modified:	20 Jun 2023 06:41
URI:	http://repository.unsri.ac.id/id/eprint/112326

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