PENGARUH PEMBERIAN ORALLY DISSOLVING FILM EKSTRAK DAUN SUNGKAI (Peronema canescens) TERHADAP SEL IMUN TIKUS PUTIH GALUR WISTAR

SALAMUDIN, ANNISA PUTRI and Agustiarini, Vitri and Miksusanti, Miksusanti (2023) PENGARUH PEMBERIAN ORALLY DISSOLVING FILM EKSTRAK DAUN SUNGKAI (Peronema canescens) TERHADAP SEL IMUN TIKUS PUTIH GALUR WISTAR. Undergraduate thesis, Sriwijaya University.

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Abstract

Peronema canescens (sungkai leaf) contains flavonoid secondary metabolites that show activity as immunostimulants. This study aims to determine the properties of Orally Dissolving Film (ODF) of sungkai leaf extract, immunomodulatory effects, macroscopic and histopathology of rat spleen. ODF was prepared using solvent casting method. Immunity parameters observed were CD4+ T cell values using PIMA analyzer and leukocytes, lymphocytes, neutrophils and monocytes using haematology analyzer. Histopathologic observation of the spleen using light microscopy with HE stain. The test animals used were male Wistar white rats with an average weight of 200 grams. The treatment was divided into 5 groups, namely normal (Feed), negative control (Placebo), positive control (Immunos), group I (0.4 mg/KgBB Extract) and group II (0.4 mg/KgBB ODF Extract). The treatment was carried out once a day for 7 days. Based on the results of the study, the evaluation results of the ODF extract properties were qualified. The results of mouse testing showed a significant increase in leukocytes in the extract and ODF extract groups (p<0.05). The results of the CD4+ value of the ODF extract group showed no significant difference with the positive control. Macroscopic observation of the spleen of the ODF extract group showed a normal spleen. The results of histopathology of the spleen of rats showed a mild degree of necrosis and hemorrhage. Based on the data of this study, it shows that Orally Dissolving Film (ODF) of sungkai leaf extract shows activity as an immunostimulant

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	CD4+, Limpa, Orally Dissolving Film, Peronema canescens
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM147-180 Administration of drugs and other therapeutic agents R Medicine > RM Therapeutics. Pharmacology > RM270-282 Immunotherapy. Serotherapy R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Annisa Putri Salamudin
Date Deposited:	05 Jul 2023 07:07
Last Modified:	05 Jul 2023 07:07
URI:	http://repository.unsri.ac.id/id/eprint/114322

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