UJI AKTIVITAS DIRETIK EKSTRAK ETANOL DAUN KETEPENG CINA (Cassia alata L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR

DWISATRIO, ARIF and Herlina, Herlina and Solihah, Indah (2019) UJI AKTIVITAS DIRETIK EKSTRAK ETANOL DAUN KETEPENG CINA (Cassia alata L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR. Undergraduate thesis, Sriwijaya University.

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Abstract

Cassia alata Linn contains flavonoid compounds which are widespread in all parts of the plants. Flavonoids are a class of phenols that have efficacy such as anti-inflamatory, antihypertensive, diuretics, and improve the work of capillary blood vessels. Cassia alata leaves contained flavonoid compounds that have been widely studied as a diuretic agent. Research used wistar male rats and divided into 5 groups, consisting of normal control group (suspension of Sodium CMC 1% 2 mL/200 gBW), positive control group (furosemide 20 mg/kgBW), and treatment groups I–III : ethanolic extract of Cassia alata Linn leaves dose of 250, 500, and 1000 mg/kgBW. Before treatment and every 3 hours, rats were given 2 mL of distilled water 2 mL/200gBW. The volume of urine was measured after the treatment every 1 hour for 6 hours and analyzed qualitatively of sodium, potassium, and cloride ions. Furosemide as a positive control produced the most volume of urine, 5.5 mL. Ethanolic extract of Cassia alata Linn leaves 1000mg/BW dose produced 3.5 ml total volume of urine and had the highest diuretic activity, 39.90%, than the other dose of ethanolic extract. ED50 value was 1437,6 mg/kgBW. Furosemide and ethanolic extract of Cassia alata Linn leaves showed the positive result of urine that contained sodium, potassium, and chloride ions.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Cassia alata Linn, flavonoid, diuretic activity
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Administrator Library
Date Deposited: 30 Jul 2019 04:42
Last Modified: 02 Aug 2019 07:07
URI: http://repository.unsri.ac.id/id/eprint/1194

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