Murti, Krisna and Lestari, Mayang Indah and Liberty, Iche Andriyani and Hafy, Zen and Linardi, Violantina and Khoirudin, Muhammad (2023) Waste anesthetic gases have a significant association with deoxyribonucleic acid (DNA) damage: A systematic review and meta-analysis of 2,732 participants. Heliyon, 9. pp. 1-13.
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Abstract
Introduction: Operating room workers are at risk of experiencing adverse effects due to occupa- tional exposure to waste anesthetic gases (WAGs). One of the consequences of long-term WAGs exposure is the probability of developing deoxyribonucleic acid (DNA) damage. This systematic review investigated the link between WAGs and DNA damage in operating room workers. Methods: PubMed, Science Direct, ProQuest, Scopus, and EbscoHost, as well as hand-searching, were used to find literature on the relationship between WAGs and DNA damage. Three inde- pendent reviewers independently assessed the study’s quality. Meta-analysis was conducted for several DNA damage indicators, such as comet assay (DNA damage score, tail’s length, tail’s DNA percentage), micronuclei formation, and total chromosomal aberration. Results: This systematic review included 29 eligible studies (2732 participants). The majority of the studies used a cross-sectional design. From our meta-analysis, which compared the extent of DNA damage in operating room workers to the unexposed group, operating room workers exposed to WAGs had a significantly higher DNA damage indicator, including DNA damage score, comet tail’s length, comet tail’s DNA percentage, micronuclei formation, and total chromosomal aberration (p < 0.05) than non-exposed group. Conclusion: Waste anesthetic gases have been found to significantly impact DNA damage in- dicators in operating room personnel, including comet assay, micronuclei development, and chromosomal aberration. To reduce the impact of exposure, hospital and operating room personnel should take preventive measures, such as by adapting scavenger method.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) > R5-920 Medicine (General) |
| Divisions: | 04-Faculty of Medicine > 11718-Pathology Anatomy (Sp |
| Depositing User: | dr., Ph.D. Krisna Murti |
| Date Deposited: | 01 Dec 2023 11:12 |
| Last Modified: | 01 Dec 2023 11:12 |
| URI: | http://repository.unsri.ac.id/id/eprint/128659 |
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