EFEK EKSTRAK DAUN KERSEN (MUNTINGIA CALABURA L.) TERHADAP PROFIL HISTOPATOLOGI SENDI TIKUS MODEL GOUT

VALENTINO, ALBERT AMADEUS and Larasati, Veny and Parisa, Nita (2023) EFEK EKSTRAK DAUN KERSEN (MUNTINGIA CALABURA L.) TERHADAP PROFIL HISTOPATOLOGI SENDI TIKUS MODEL GOUT. Undergraduate thesis, Sriwijaya University.

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Abstract

Background: Acute gouty arthritis is an inflammation caused by MSU crystal deposition in the joint. Kersen leaves contain flavonoids that have anti-inflammatory and antioxidant activities. This study aims to determine the effect of kersen (Muntingia calabura L.) leaf extract on the histopathological profile of gout model rat joints. Methods: This research is an in vivo post-test-only control group experimental study. Kersen leaf ethanol extract (EEMC) was prepared by macerating kersen leaf simplicia with 96% ethanol. Thirty male Wistar rats were divided into five groups: normal control, negative control (Na-CMC 0.5%), and three groups of kersen leaf extract doses of 200, 400, and 800 mg/kgBW. Rats in the negative control and extract groups were injected by MSU crystal suspension intraarticularly to make a gout model. Rats were terminated on the third day, and knee joints were taken for HE slides. A histopathological examination was performed by assessing the synovial inflammation and cartilage erosion profile scores. The data were then analyzed using SPSS with a statistical significance of p < 0,05. Results: The synovial inflammation and cartilage erosion profile scores obtained from each group, respectively, were 0,67 and 0,67; 3,17 and 6,00; 3,33 and 2,17; 1,67 and 0,83; and 1,83 and 1,33. Between groups, there were significant differences in cartilage erosion profile scores and non-significant differences in synovial inflammation profile scores. Conclusion: EEMC has an effect on improving the cartilage erosion profile score but has no effect on improving the synovial inflammation profile score in the knee joint of gouty rat models. Keywords: Kersen leaf extract, Muntingia calabura L., Gout arthritis, Synovial inflammation, Cartilage erosion

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Ekstrak Daun Kersen, Muntingia calabura L., Artritis Gout, Inflamasi Sinovium, Erosi Kartilago
Subjects:	R Medicine > RB Pathology > RB24-33 Pathological anatomy and histology R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Albert Amadeus Valentino
Date Deposited:	20 Dec 2023 01:56
Last Modified:	20 Dec 2023 01:56
URI:	http://repository.unsri.ac.id/id/eprint/135969

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