EFEK EKSTRAK DAUN KERSEN (Muntingia calabura L.) TERHADAP KADAR TNF-α PADA TIKUS WISTAR MODEL GOUT ARTRITIS AKUT

TANTORO, VALYN THEODRA and Parisa, Nita and Theodorus, Theodorus (2023) EFEK EKSTRAK DAUN KERSEN (Muntingia calabura L.) TERHADAP KADAR TNF-α PADA TIKUS WISTAR MODEL GOUT ARTRITIS AKUT. Undergraduate thesis, Sriwijaya University.

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Abstract

Background: Acute gout arthritis is an inflammation due to the accumulation of MSU crystal in the joint which leads to pain, swelling, and an increase in proinflammatory cytokines such as TNF-α. Cherry leaves contain flavonoids that have anti-inflammatory activity which plays a role in inhibiting the production of TNF-α. This study aims to determine the anti-infammatory effect of cherry leaves extract (Muntingia calabura L.) on serum TNF-α levels in wistar rats as a model of acute gout arthritis. Methods: An in vivo experimental study with a pre and post-test control group design has been conducted at the Faculty of Medicine, Universitas Sriwijaya in August-December 2023. After the acclimatization period, male wistar rats were divided into 5 treatment groups, each consisting of 6 rats; negative control (Na-CMC 0,5%), positive control (Colchicine), D1 (cherry leaves extract dose 200 mg/kgBW), D2 (cherry leaves extract dose 400 mg/kgBW), D3 (cherry leaves extract dose 800 mg/kgBW). Acute gout arthritis rat models were created by intra-articular injection of 50µl MSU crystal suspension into the synovial joint of the knee. After the induction of MSU crystal, TNF-α levels in the blood were examined twice, before and after treatment, using Rat ELISA TNF-α. Results: The cherry leaves extract showed effectiveness in significantly reducing TNF-α levels (Paired T-test p<0,05) compared to the negative control. The most effective dose was cherry leaves extract at a dose of 200mg/kgBW, which was comparable to the positive control colchicine (Independent T-test p>0,05) Conclusion: Cherry leaves extract can reduce inflammatory responses by reducing TNF-α levels serum in acute gout arthritis model rat models. Keywords: Gout arthritis, TNF-α, Inflammatory mediator, Cherry leaves extract, Therapy

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Gout Artritis, TNF-α, Mediator Inflamasi, Ekstrak daun kersen, Terapi
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Valyn Theodra Tantoro
Date Deposited:	21 Dec 2023 03:21
Last Modified:	21 Dec 2023 03:21
URI:	http://repository.unsri.ac.id/id/eprint/136774

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