HUBUNGAN BCR-ABL1, GAMBARAN KLINIS, DAN LABORATORIUM HEMATOLOGIS DENGAN FASE DARI LEUKEMIA MIELOSITIK KRONIK DEWASA

ISLAMIAH, DANIA PUTRI and Liana, Phey and Rahadiyanto, Kemas Ya'kub (2023) HUBUNGAN BCR-ABL1, GAMBARAN KLINIS, DAN LABORATORIUM HEMATOLOGIS DENGAN FASE DARI LEUKEMIA MIELOSITIK KRONIK DEWASA. Undergraduate thesis, Sriwijaya University.

	Text RAMA_11201_04011182025017.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (8MB) | Request a copy
	Text RAMA_11201_04011182025017_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (6MB) | Request a copy
	Text RAMA_11201_04011182025017_0003088102_0012017201_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (8MB)
	Text RAMA_11201_04011182025017_0003088102_0012017201_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (8MB) | Request a copy
	Text RAMA_11201_04011182025017_0003088102_0012017201_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (8MB) | Request a copy
	Text RAMA_11201_04011182025017_0003088102_0012017201_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (8MB) | Request a copy
	Text RAMA_11201_04011182025017_0003088102_0012017201_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (8MB) | Request a copy
	Text RAMA_11201_04011182025017_0003088102_0012017201_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (8MB) | Request a copy
	Text RAMA_11201_04011182025017_0003088102_0012017201_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (8MB) | Request a copy

Abstract

Background: Chronic Myeloid Leukemia (CML) is a leukemia subtype, accounts for 15% of adult leukemia. CML progression occurs in chronic, accelerated, and blast phases. Common clinical manifestations include anemia, splenomegaly, and other symptoms such as fatigue, weight loss, etc. In cases suspected of CML, a complete blood count is the initial examination. Diagnostic confirmation then achieved through the identification of the breakpoint cluster region Abelson (BCR-ABL1). Despite its crucial role, qualitative and quantitative BCR-ABL1 examinations incur relatively high costs. This study aims to analyze the relationship between the phases of CML and qualitative BCR-ABL1, quantitative BCR-ABL1, clinical presentations, and hematologic laboratory parameters in adult CML patients. Methods: This study is an analytical observational study with a cross-sectional design. The sample was the inpatient medical records of adult CML patients at Dr. Mohammad Hoesin Hospital Palembang January 2019-June 2023 which met the inclusion criteria and were devoid of exclusion criteria. Sampling were conducted through total sampling. The data were analyzed using SPSS V22. Results: Among the 95 samples, there were 80 CML patients in chronic phase and 15 patients in accelerated-blast phase. The results of this study indicate a significant difference between qualitative BCR-ABL1 and the CML phase (p<0.001). Furthermore, there are statistically significant differences observed in the median platelet count as well as the mean neutrophil count in relation to the CML phase (p=0.015 and p=0.002, respectively). Conclusion: There was a significant difference between qualitative BCR-ABL1, platelet, and neutrophil levels in the phases of CML, suggesting that these parameters may be considered as initial examinations to estimate the disease phase. Keywords: BCR-ABL1, Clinical Manifestations, Hematological Features, Chronic Myelocytic Leukemia

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	BCR-ABL1, Gambaran Klinis, Gambaran Laboratorium Hematologis, Leukemia Mielositik Kronik
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > RB Pathology > RB37-56.5 Clinical pathology. Laboratory technique
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Dania Putri Islamiah
Date Deposited:	21 Dec 2023 05:40
Last Modified:	21 Dec 2023 05:40
URI:	http://repository.unsri.ac.id/id/eprint/136806

Available Versions of this Item

• HUBUNGAN BCR-ABL1, GAMBARAN KLINIS, DAN LABORATORIUM HEMATOLOGIS DENGAN FASE DARI LEUKEMIA MIELOSITIK KRONIK DEWASA. (deposited 19 Dec 2023 05:26)
  • HUBUNGAN BCR-ABL1, GAMBARAN KLINIS, DAN LABORATORIUM HEMATOLOGIS DENGAN FASE DARI LEUKEMIA MIELOSITIK KRONIK DEWASA. (deposited 21 Dec 2023 05:40) [Currently Displayed]

Actions (login required)

View Item