EFEK INTERMITTENT FASTING TERHADAP GAMBARAN HISTOPATOLOGI JARINGAN HEPAR

LESTARI, ADE AYU and Larasati, Veny and Fertilita, Soilia (2023) EFEK INTERMITTENT FASTING TERHADAP GAMBARAN HISTOPATOLOGI JARINGAN HEPAR. Undergraduate thesis, Sriwijaya University.

	Text RAMA_11201_04011382025226.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (24MB) | Request a copy
	Text RAMA_11201_04011382025226_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (18MB) | Request a copy
	Text RAMA_11201_04011382025226_0227108501_0008108305_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (6MB)
	Text RAMA_11201_04011382025226_0227108501_0008108305_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (8MB) | Request a copy
	Text RAMA_11201_04011382025226_0227108501_0008108305_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (224kB) | Request a copy
	Text RAMA_11201_04011382025226_0227108501_0008108305_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (4MB) | Request a copy
	Text RAMA_11201_04011382025226_0227108501_0008108305_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (84kB) | Request a copy
	Text RAMA_11201_04011382025226_0227108501_0008108305_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (91kB) | Request a copy
	Text RAMA_11201_04011382025226_0227108501_0008108305_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy

Abstract

Background: Obesity is a condition characterized by the excessive accumulation of body fat, also the reason for insulin resistance, as lipid buildup in the liver triggers an inflammatory process. Inflammatory mediators in the liver are activated by Kupffer cells to produce cytokines pro inflammation. Prevention and management of obesity can be achieved through dietary modification intermittent fasting approach, specifically time-restricted feeding. This research aims to determine whether there are changes in the histology of liver tissue in a mice model of obesity subjected to intermittent fasting with a time-restricted feeding approach. Methods: This research used a cross-sectional method. The obtained data consisted of secondary biological material, specifically histological preparations of mice (Mus musculus) liver tissue from Muhammad Farhan's research (2023) that met the inclusion criteria. Preparations were divided into three groups based on the treatments given. Results: Successively, the number of Kupffer cells per group (cells/field of view) is 24,900 ± 10,805; 35,300 ± 10,306; and 33,020 ± 9,211. The number of steatosis per group (cells/field of view) is 0.003 ± 0.004; 0.011 ± 0.007; and 0.002 ± 0.003. The normal control group shows a significant difference in the number of Kupffer cells. The obesity group has a significant difference in the number of steatosis. Conclusion: Time-restricted feeding intermittent fasting does not have a statistically significant effect on the number of Kupffer cells in the obesity group. Time-restricted feeding intermittent fasting has a statistically significant effect on the number of steatosis in the obesity group. Keywords: Intermittent fasting, time-restricted feeding, steatosis, Kupffer cells

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Intermittent fasting, time-restricted feeding, steatosis, sel kupffer
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > R Medicine (General) > R702-703 Medicine and the humanities. Medicine and disease in relation to history, literature, etc. R Medicine > RB Pathology > RB24-33 Pathological anatomy and histology
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Ade Ayu Lestari
Date Deposited:	02 Jan 2024 07:34
Last Modified:	02 Jan 2024 07:34
URI:	http://repository.unsri.ac.id/id/eprint/137348

Actions (login required)

View Item