DISTRIBUSI BAKTERI DAN POLA KEPEKAAN ANTIBIOTIK ISOLAT BAKTERIURIA PADA ANAK DENGAN KEGANASAN DISERTAI DEMAM NEUTROPENIA DI RSUP DR. MOHAMMAD HOESIN PALEMBANG

INDRIANI, HALIMAH and Iriani, Yulia and Rivani, Erizka (2024) DISTRIBUSI BAKTERI DAN POLA KEPEKAAN ANTIBIOTIK ISOLAT BAKTERIURIA PADA ANAK DENGAN KEGANASAN DISERTAI DEMAM NEUTROPENIA DI RSUP DR. MOHAMMAD HOESIN PALEMBANG. Undergraduate thesis, Sriwijaya University.

	Text RAMA_11201_04011182025027.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_11201_04011182025027_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (6MB) | Request a copy
	Text RAMA_11201_04011182025027_8896020016_0029129101_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (683kB)
	Text RAMA_11201_04011182025027_8896020016_0029129101_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (320kB) | Request a copy
	Text RAMA_11201_04011182025027_8896020016_0029129101_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (346kB) | Request a copy
	Text RAMA_11201_04011182025027_8896020016_0029129101_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (672kB) | Request a copy
	Text RAMA_11201_04011182025027_8896020016_0029129101_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (177kB) | Request a copy
	Text RAMA_11201_04011182025027_8896020016_0029129101_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (189kB) | Request a copy
	Text RAMA_11201_04011182025027_8896020016_0029129101_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy

Abstract

Background: Urinary tract infection (UTI) is one of the etiologies of febrile neutropenia (FN) in pediatric malignancy, an oncology emergency. Empirical antibiotic prescribing according to guidelines, based on local bacterial and resistance patterns, should be initiated immediately. This study aims to determine the prevalence of UTI, the distribution of bacterial and antibiotic sensitivity patterns of bacteriuria isolates in FN. Methods: This was a descriptive observational study with a cross-sectional design. The study was undertaken at Dr. Mohammad Hoesin Hospital Palembang retrospectively, using data on results of urine culture and antibiotic sensitivity tests in children with febrile neutropenia and malignancies from January 2020 to December 2022. Results: Urine culture was performed in 158 out of 458 episodes of FN in children with malignancy, with a proportion of UTI (33.5%). Most UTIs in FN occurred in early adolescence (12-18 tahun) (41.5%), females (54.7%), and hematologic malignancies (75.5%) dominated by acute lymphoblastic leukemia (51%). The bacteria causing UTIs were mostly Gram-negative (79.3%), with Escherichia coli being the dominant bacterial species (28.9%), Acinetobacter baumannii (13.6%), Enterococcus faecalis (11.9%) and Klebsiella pneumoniae (8.5%). Cephalosporin class antibiotic sensitivities for Eschericia coli and other Gram-negative isolates were <80%, most sensitive to meropenem (100%), amikacin (100%) and tigecycline (100%). In 82.3% of Escherichia coli bacteria were multi-drug resistant isolates. Conclusion: One-third of children with febrile neutropenia who underwent urine culture had UTI. Gram-negative bacteria were the most common etiologies of UTIs, with Escherichia coli predominant. Escherichia coli were most sensitive to meropenem, amikacin, and tigecycline. Key words: Febrile neutopenia, Pediatric malignancy, Urinary tract infection, Antibiotic sensitivity test.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Febrile neutopenia, Pediatric malignancy, Urinary tract infection, Antibiotic sensitivity test.
Subjects:	R Medicine > RJ Pediatrics > RJ370-550 Diseases of children and adolescents
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Halimah Indriani
Date Deposited:	11 Jan 2024 08:24
Last Modified:	11 Jan 2024 08:24
URI:	http://repository.unsri.ac.id/id/eprint/137948

Actions (login required)

View Item