OPTIMASI FORMULASI NANOPARTIKEL KITOSAN-ALGINAT PEMBAWA KATEKIN TERKONJUGASI ASAM FOLAT

ARUM, PUTERI SEKAR and Shiyan, Shaum (2024) OPTIMASI FORMULASI NANOPARTIKEL KITOSAN-ALGINAT PEMBAWA KATEKIN TERKONJUGASI ASAM FOLAT. Undergraduate thesis, Sriwijaya University.

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Abstract

Catechins are natural compounds in the phenolic group with anti-cancer activity. However, catechins have low bioavailability in the gastrointestinal tract which can affect the pharmacological activity of catechins, so modification of the delivery system in the form of nanoparticles with a combination of folic acid conjugated chitosan-alginate coating is required. The aim of this research is to obtain an optimum formula to produce catechin carrier nanoparticles with the best characteristics. Chitosan-alginate nanoparticles carrying folic acid-conjugated catechins were made using the ionic gelation method with varying coating concentrations, then characterized including particle size, polydispersity index, zeta potential, and encapsulation efficiency. The coating concentration was varied with a chitosan-alginate ratio of 0.3:0.3 (F1), 0.6;0.3 (F2), 0.3:0.6 (F3), and 0.6:0.6 (F4). The optimum formula was determined using Design Expert 12® software, and re-characterization and evaluation tests were carried out in the form of stability tests, In-Vitro drug release and drug release kinetic profiles. A high chitosan concentration results in a larger particle size and polydispersity index and a smaller encapsulation efficiency. The higher alginate concentration produces small particle sizes, large polydispersity index, smaller zeta potential and greater encapsulation efficiency. The optimum formula was achieved by F3 with a polymer concentration of 0.3% chitosan and 0.6% alginate. The optimum formula obtained has the characteristics of an average particle size of 241,1 nm, a polydispersity index of 0,334, and a zeta potential of -40,87 mV. F3 was proven to be able to maintain physical stability for 12 days of testing, had a maximum release capacity of 70,828% at 24 hours and had drug release kinetics through a diffusion process and was classified as a Higuchi model

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Kitosan, Asam Folat, Alginat, Nanopartikel, Katekin
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Puteri Sekar Arum
Date Deposited:	15 Jan 2024 06:44
Last Modified:	15 Jan 2024 06:44
URI:	http://repository.unsri.ac.id/id/eprint/138204

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