AKTIVITAS ANTIBAKTERI DAUN SAMBILOTO DENGAN KOMBINASI TWEEN 80 DAN PEG-400 TERHADAP BAKTERI PROPIONIBACTERIUM ACNES SERTA UJI STABILITAS ICH Q1A(R2)

TANIA, SAZKIA DWI and Apriani, Elsa Fitria and Hardestyariki, Dwi (2024) AKTIVITAS ANTIBAKTERI DAUN SAMBILOTO DENGAN KOMBINASI TWEEN 80 DAN PEG-400 TERHADAP BAKTERI PROPIONIBACTERIUM ACNES SERTA UJI STABILITAS ICH Q1A(R2). Undergraduate thesis, Sriwijaya University.

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Abstract

Andrographis paniculata (Burm.f.) Wall. Ex Ness. has potential as an antibacterial agen due to its phytochemical compounds. Nanoemulsion was chosen as a potential formulation due to its ability to increase the bioavailability, stability and antibacterial activity of the sambiloto leaves. This study aims to determine the stability and antibacterial activity of nanoemulsion with a combination of Tween 80 and PEG-400 against Propionibacterium acnes. Nanoemulsion was tested for stability with ICH Q1A (R2) standard using accelerated test, and antibacterial activity was tested with diffusion method to determine the diameter of the inhibition zone and dilution method to determine the minimum inhibitory concentration (KHM) Nanoemulsion of basil produced gave organoleptic characteristics of dark green color, basil odor and clear with pH of 6.426 ± 0.009, specific gravity of 1.061 ± 0.001, viscosity of 81.000 ± 0.000 cps, percent transmittance of 99.466 ± 0.094%, andrografolid content of 108, 482 ± 0.093%, encapsulation efficiency of 98.086 ± 0.000%, globule size of 173.633 ± 71.290 nm, polydispersity index of 0.323 ± 0.060 and zeta potential of -15.9 ± 0.244 mV. The stability test results showed that the nanoemulsion of sambiloto extract had a first-order release model, an activation energy of 200.1169 cal/mol and had a shelf life under 25℃±2℃/60% RH±5% RH conditions for 50.658 days and at 5oC storage conditions for 72.505 days. The diameter of the inhibition zone of nanoemulsion of sambiloto extract showed a strong inhibition response of 14,000 ± 0.816 mm and the minimum inhibition concentration value of 80 mg/ml. Based on the results, it can be concluded that nanoemulsion of sambiloto extract has good characterization and stability as well as strong antibacterial activity against Propionibacterium acnes.

Item Type: Thesis (Undergraduate)
Subjects: R Medicine > RL Dermatology > RL201-331 Hyperemias, inflammations, and infections of the skin
R Medicine > RS Pharmacy and materia medica > RS125-131.9 Formularies. Collected prescriptions
R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions: 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Sazkia Dwi Tania
Date Deposited: 19 Jan 2024 03:26
Last Modified: 19 Jan 2024 03:26
URI: http://repository.unsri.ac.id/id/eprint/138655

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