AMARI, SALSABILA PUTRI and Apriani, Elsa Fitria and Ahmadi, Adik (2024) STUDI STABILITAS PROTRANSETOSOM KLINDAMISIN HCL DENGAN LIOPROTEKTAN TREHALOSA MENGGUNAKAN METODE ICH Q1A (R2). Undergraduate thesis, Sriwijaya University.
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Abstract
Clindamycin HCl as a topical anti-acne drug has low bioavailability due to its hydrophilic nature which is difficult to penetrate the stratum corneum. Propionibacterium acnes, the main pathogen of acne, lives in the sebaceous glands in the dermis, so it requires deeper penetration. Transethosomes can increase penetration because they are classified as lipid nanovesicles with good elasticity and permeability. However, transethosomes have shortcoming in storage stability because they contain phospholipids which are easily degraded. This research aims to improve the stability of clindamycin HCl transethosomes through lyophilization and addition of trehalose as lyoprotectant. Trehalose is added at 5:1 to lipids to protect vesicles during lyophilization which involves extreme temperatures. The characterization results showed that the lyophilized transethosomes with trehalose can significantly improve the entrapment efficiency from 92.700% to 99.556% and the particle size from 343.667 nm to 219.300 nm; and maintain the polydispersity index from 0.513 to 0.547 and the zeta potential from -32.233 mV to -34.933 mV. The formula obtained was continued for ICH Q1A (R2) stability study and in vitro release study. Stability study showed that lyophilization and addition of trehalose can increase the shelf life of transethosomes from 28 days to 208 days at 25°C. Release study showed that protransethosomal gel has better and more sustained penetration than non-transethosomal gel by following zero-order release kinetics. Based on the research results, the development of transethosomes into protransethosomes through lyophilization and addition of trehalose can increase storage stability and penetration of clindamycin HCl into in vitro cell membrane.
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Uncontrolled Keywords: | Kinetika pelepasan, klindamisin HCl, protransetosom, trehalosa, stabilitas |
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology |
| Divisions: | 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1) |
| Depositing User: | Salsabila Putri Amari |
| Date Deposited: | 19 Jan 2024 06:48 |
| Last Modified: | 19 Jan 2024 06:48 |
| URI: | http://repository.unsri.ac.id/id/eprint/138914 |
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