EFEK PEMBERIAN SELF-NANO EMULSION (UNCARIA GAMBIR ROXB.) TERHADAP PROFIL NEUROPROTEKTIF, STRES OKSIDATIF DAN MIKROANATOMI OTAK PADA MODEL TIKUS DIABETES MELITUS TIPE 2 SEBAGAI UPAYA PREVENTIF ALZHEIMER

PUTRI, NADIYA SHELANDA and Shiyan, Shaum (2024) EFEK PEMBERIAN SELF-NANO EMULSION (UNCARIA GAMBIR ROXB.) TERHADAP PROFIL NEUROPROTEKTIF, STRES OKSIDATIF DAN MIKROANATOMI OTAK PADA MODEL TIKUS DIABETES MELITUS TIPE 2 SEBAGAI UPAYA PREVENTIF ALZHEIMER. Undergraduate thesis, Sriwijaya University.

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Abstract

Diabetes mellitus (DM) can cause cognitive disorders and even Alzheimer's disorders. Catechins in gambier have pharmacological effects as antioxidants and can be used as therapy to improve cognitive function and prevent Alzheimer's disease. The research aims to determine the characteristics of gambier extract and SNE as active anti-diabetic ingredients to prevent Alzheimer's disease and to determine the effect of SNE gambier extract on anti-diabetes in preventing Alzheimer's disease. The research subjects used six groups of white Wistar rats. Normal group, negative control group with STZ-NA induction 45mg/kgBW. Group positive for glibenclamide 5mg/kgBW, group 1 SNE basic dose 40mg/kgBW, group 2 SNE gambier extract 60mg/kgBW, group 3 gambier extract 60mg/kgBW. Data were analyzed using the One Way Anova test and continued with the Post-Hoc Tuke or Kruskal-Wallis test. The ANOVA results showed a p value <0.05 so there were significant differences between treatments in the parameters of fasting glucose, SOD, CAT and MDA. The research results show that administration of SNE gambier extract is an effective drug delivery system as an antioxidant and as a prevention of Alzheimer's disease. Keywords: Alzheimer's, CAT Diabetes Mellitus, Gambier, Catechin, SOD and MDA, SNE

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Alzheimer, CAT Diabetes Mellitus, Gambir, Katekin, SOD dan MDA, SNE
Subjects:	Q Science > QM Human anatomy > QM550-577.8 Human and comparative histology R Medicine > RS Pharmacy and materia medica > RS125-131.9 Formularies. Collected prescriptions R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Nadiya Shelanda Putri
Date Deposited:	23 Feb 2024 01:45
Last Modified:	23 Feb 2024 01:45
URI:	http://repository.unsri.ac.id/id/eprint/141030

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