CXC Motif Chemokine Receptor 2: Glimpses into the Molecular Pathogenesis of Placenta Accreta Spectrum Disorder

Murti, Krisna and Mirani, Putri and Lestari, Peby Maulina and Liberty, Iche Andriyani and Andrina, Hana and Kesty, Cindy and Stevanny, Bella (2024) CXC Motif Chemokine Receptor 2: Glimpses into the Molecular Pathogenesis of Placenta Accreta Spectrum Disorder. Indonesian Journal of Obstetrics & Gynecology Science, 7 (1). pp. 16-22. ISSN 2615-496X

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Abstract

Investigation into the mechanism underlying excessive trophoblast invasion yields further strategies and insights for the diagnosis and treatment of placenta accreta spectrum disorder (PASD). We conducted a comprehensive literature review to analyze the relationship between CXCR2 expression and PASD, as well as the possibility of CXCR2 being used as a therapeutic and diagnostic biomarker for PASD. Chemokines are well-known mediators in the immune system, particularly for cell recruitment, angiogenesis, and tumor infiltration. CXCR2 is an important component of the immune system, particularly in neutrophils. One of the CXCR2 ligands, IL-8, has also been found to be expressed in the decidua and trophoblasts of humans and to promote autocrine or paracrine trophoblast migration and invasion. The potential role of CXCR2 in trophoblast invasion in PASD provides researchers with a glimpse into the molecular pathogenesis of PASD. Key words: biomarker; CXCR2; placenta accreta Key words: biomarker; CXCR2; placenta accreta

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) #3 Repository of Lecturer Academic Credit Systems (TPAK) > Articles Access for TPAK (Not Open Sources)
Divisions:	04-Faculty of Medicine > 11718-Pathology Anatomy (Sp
Depositing User:	dr., Ph.D. Krisna Murti
Date Deposited:	27 Mar 2024 08:36
Last Modified:	27 Mar 2024 08:36
URI:	http://repository.unsri.ac.id/id/eprint/142156

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