Matrix Metalloproteinase-9 in the Etiopathogenesis of Placenta Accreta Spectrum: A Literature Review

Murti, Krisna and Mirani, Putri and Lestari, Peby Maulina and Liberty, Iche Andriyani and Andrina, Hana and Kesty, Cindy and Stevanny, Bella (2024) Matrix Metalloproteinase-9 in the Etiopathogenesis of Placenta Accreta Spectrum: A Literature Review. Journal of Maternal-Fetal Medicine, 6 (2). pp. 97-101. ISSN 2096-6954

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Abstract

Abstract The recent increase in placenta accreta spectrum has been correlated with a rise in the rate of cesarean sections. A recent study provides evidence that hampered wound healing results in cesarean scar defects that lead to a failure in the normal process of decidualization and deeper adherence of trophoblasts. Matrix metalloproteinase (MMP) is crucial in every step of wound healing as it alters the wound matrix, facilitating cell migration, as well as tissue remodeling. MMP-9 expression is higher in placental and decidual tissue in cases of placenta accreta. Based on these findings, assessment of MMP-9 expression can shed new light on the etiopathology of placenta accreta spectrum disorder and can be a potential diagnostic marker. Keywords: Biomarker; Etiopathogenesis; Matrix metalloproteinase; MMP-9; Placenta accreta spectrum disorder

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) #3 Repository of Lecturer Academic Credit Systems (TPAK) > Articles Access for TPAK (Not Open Sources)
Divisions:	04-Faculty of Medicine > 11718-Pathology Anatomy (Sp
Depositing User:	dr., Ph.D. Krisna Murti
Date Deposited:	09 May 2024 07:36
Last Modified:	09 May 2024 07:36
URI:	http://repository.unsri.ac.id/id/eprint/143413

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