Murti, Krisna and Kusnadi, Yulianto and Saleh, Mgs. Irsan and Ali, Zulkhair and Hermansyah, Hermansyah and Hafy, Zen and Yuristo, N.S Eddy (2023) Similarity Result of_Firmicutes/Bacteroidetes Ratio of Gut Microbiota and Its Relationships with Clinical Parameters of Type 2 Diabetes Mellitus: A Systematic Review. Turnitin Universitas Sriwijaya, Turnitin Universitas Sriwijaya. (Submitted)
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Abstract
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a global health problem with multifactorial etiopathogenesis. Recent studies show gut microbiota dysbiosis that plays a crucial role in pathogenesis and complications of T2DM. Firmicutes and Bacteroidetes phylum ratio (F/B ratio) is one of the markers for gut microbiota dysbiosis which remains to be investigated in recent decades. AIM: The present study summarized the correlation between B/F ratio with some clinical parameters of T2DM. METHODS: A systematic review of the literature for clinical studies was performed on PubMed, ProQuest, and Google Scholar. Studies were assessed for risk of bias using Newcastle–Ottawa scale. All observational cross- sectional, case–control, and cohort studies that studied F/B or B/F ratio in T2DM were included. Key evidence was analyzed and qualitatively synthesized. RESULT: Seven relevant studies were included. Five studies were high-quality and two studies were medium-quality. The F/B ratio of the gut microbiota varies in different types of T2DM and is associated with different clinical parameters. The F/B ratio decreased inT2DM and had significant negative correlation with OGTT blood glucose but had unsignificant correlation with fasting fasting blood glucose, postprandial blood glucose, and HbA1C. The F/B ratio might increase in T2DM and was positively correlated with lean tissue index and associated with the wider left atrial size. CONCLUSION: Current systematic review demonstrated that intestinal microbiota dysbiosis played a key role in the pathogenesis of T2DM. The gut microbiota F/B ratio was varied and was associated with various clinical parameters in T2DM
| Item Type: | Other |
|---|---|
| Subjects: | R Medicine > R Medicine (General) > R5-920 Medicine (General) #3 Repository of Lecturer Academic Credit Systems (TPAK) > Results of Ithenticate Plagiarism and Similarity Checker |
| Divisions: | 04-Faculty of Medicine > 11718-Pathology Anatomy (Sp |
| Depositing User: | dr., Ph.D. Krisna Murti |
| Date Deposited: | 05 Jul 2024 23:13 |
| Last Modified: | 05 Jul 2024 23:13 |
| URI: | http://repository.unsri.ac.id/id/eprint/148727 |
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