KARAKTERISTIK FILM KITOSAN (Scylla serrata) DENGAN PENGENTAL XANTHAN GUM SEBAGAI MEDIA PENGHANTARAN OBAT DALAM TERAPI PERIODONTAL

RAHMANIYAH, YULIA and Negara, Mellani Cindera and Trisnawaty K., Trisnawaty K. (2024) KARAKTERISTIK FILM KITOSAN (Scylla serrata) DENGAN PENGENTAL XANTHAN GUM SEBAGAI MEDIA PENGHANTARAN OBAT DALAM TERAPI PERIODONTAL. Undergraduate thesis, Sriwijaya University.

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Abstract

Background: Mangrove crab production produces crab shell waste as much as 75% of the total production. The chitin content in crab shells can be utilized as a raw material for chitosan. Chitosan combined with xanthan gum can be used as raw material for making periodontal films. Objective: To determine the characteristics of chitosan (Scylla serrata) film with xanthan gum thickener as a drug delivery medium in periodontal therapy. Methods: This study is a quantitative descriptive study with the subject in the form of chitosan (Scylla serrata) film with xanthan gum thickener. The sample consisted of 1 type of chitosan film with xanthan gum thickener which was cut to the size according to the standard of film characteristic test equipment. Results: This study showed a film thickness of 0.3 mm with a weight of 0.0583 g, and a film pH of 7.15 which is classified as neutral. The film has good stability with a percentage loss of water content of 5.8% and a high swelling index value of 40.3%. This indicates a longer residence time of the film while in the periodontal pockets. The film has good flexibility with a folding resistance of 573 folds, a tensile strength of 1,634 N/mm2 and a percent elongation of 18.75%. The drug distribution in the film was well absorbed and dispersed by showing a drug content of 86.80%. Conclusion: Films of chitosan (Scylla serrata) with xanthan gum thickener have met the requirements for characteristics as a preparation in drug delivery systems, especially for periodontal therapy.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Film, kitosan (Scylla serrata), terapi periodontal, xanthan gum
Subjects:	R Medicine > RK Dentistry > RK1-715 Dentistry
Divisions:	04-Faculty of Medicine > 12201-Dentistry (S1)
Depositing User:	Yulia Rahmaniyah
Date Deposited:	16 Jul 2024 07:24
Last Modified:	16 Jul 2024 07:25
URI:	http://repository.unsri.ac.id/id/eprint/151159

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