Similarity result of_KI67 PROLIFERATION INDEX AND ITS ASSOCIATION WITH DIFFUSE LARGE B-CELL LYMPHOMA STAGE

Murti, Krisna and Ramkita, Nora and Maulani, Heni and Liberty, Iche Andriyani (2024) Similarity result of_KI67 PROLIFERATION INDEX AND ITS ASSOCIATION WITH DIFFUSE LARGE B-CELL LYMPHOMA STAGE. Turnitin Universitas Sriwijaya, Turnitin Universitas Sriwijaya. (Submitted)

Text similarity KI67 PROLIFERATION INDEX AND ITS ASSOCIATION WITH DIFFUSE LARGE B-CELL LYMPHOMA STAGE.pdf Download (2MB)

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common invasive subtype of NHL, with an increasing incidence of 150,000 new cases worldwide each year. The Ann Arbor staging system categorizes DLBCL into four stages. Ki67 immunohistochemical examination is a proliferation marker and is used as a prognostic and predictive marker in various organs. This study was conducted to determine the relationship between the Ki67 index, clinicopathological features, and DLBCL stage.This study is an observational analytic study with a crosssectional retrospective study design using 40 samples of slide archives of DLBCL cases. The sampling method was purposive sampling of DLBCL specimens from January 2019 to December 2021. Staging data is obtained through medical records and based on Ann Arbor staging system assessments. The Ki67 index was assessed on tumor hot spots and averaged in percentage. Categorized as low and high, with a cut-off point value of 85%. The relationship between the Ki67 index and stage was analyzed using Fisher's exact test.Fisher's exact test showed a significant association between the Ki67 index and the DLBCL stage, with a p-value of 0.002. There was no significant association between age, gender, location, and subtype, with p-values of 0.201, 0.607, 0.132, and 0.105, respectively.There is a significant correlation between the Ki67 index (>85%) and the DLBCL stage. Keywords: Diffuse large B-cell lymphoma; Ki67 index; stage; Hans algorithm; proliverative index

Item Type:	Other
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > RB Pathology > RB1-214 Pathology #3 Repository of Lecturer Academic Credit Systems (TPAK) > Articles Access for TPAK (Not Open Sources) #3 Repository of Lecturer Academic Credit Systems (TPAK) > Results of Ithenticate Plagiarism and Similarity Checker
Divisions:	04-Faculty of Medicine > 11718-Pathology Anatomy (Sp
Depositing User:	dr., Ph.D. Krisna Murti
Date Deposited:	31 Jul 2024 22:26
Last Modified:	31 Jul 2024 22:26
URI:	http://repository.unsri.ac.id/id/eprint/151633

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