UJI AKTIVITAS PENYEMBUHAN LUKA TERBUKA FRAKSI ETIL ASETAT DAUN SINGKONG (Manihot esculenta) PADA TIKUS PUTIH JANTAN GALUR SPRAGUE DAWLEY

NURHASANAH, SARI ANGGUN and Miksusanti, Miksusanti and Amriani, Annisa (2024) UJI AKTIVITAS PENYEMBUHAN LUKA TERBUKA FRAKSI ETIL ASETAT DAUN SINGKONG (Manihot esculenta) PADA TIKUS PUTIH JANTAN GALUR SPRAGUE DAWLEY. Undergraduate thesis, Sriwijaya University.

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Abstract

National injury prevalence tends to increase every year. Wounds must be healed immediately because they are an important role in maintaining homeostasis and have the potential to become chronic infections if not treated. Cassava leaves (Manihot esculenta) contain the main substance rutin or quercetin 3-O-rutinoside (flavonoids) and contain saponins and tannins as anti-inflammatory, antibacterial and antioxidant which can help the wound healing process. This research is aiming to find the effect of giving ethyl acetate from cassava leaf fraction towards open wound healing rate. The test animal that consist of 25 Sprague Dawley rats, divided into 5 groups which consist of negative control test, positive control test, control test K1, K2, and K3. The observed parameter include wound diameter, wound healing time, and healing percentage. Diameter of wound was analyzed using ANOVA test to observe the differences between certain days of the observation. The research result shows that ethyl acetate fraction from cassava leaf (Manihot esculenta) with 20% dossage is proven to accelerate the healing rate in rats that achieved healing rate of 100% in 14 days, where there was no significant difference (p>0,05) between cassava leaf fraction at a dose of 20% against the positive control (Tekasol®) and significantly different from the negative control. Also, there is significant difference (p <0,05) between negative control and all control groups (positive, K1, K2, dan K3) on day 14. This shows that positive control and treatment with dosage variation can accelerate the healing rate on open wound.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Cassava leaves (Manihot esculenta), wounded diameter, duration of wound healing, percentage of wound healing
Subjects:	R Medicine > RS Pharmacy and materia medica > RS400-431 Pharmaceutical chemistry
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	SARI ANGGUN NURHASANAH
Date Deposited:	22 Jul 2024 06:44
Last Modified:	22 Jul 2024 06:44
URI:	http://repository.unsri.ac.id/id/eprint/152659

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