Similarity result of_Platelet‑rich Fibrin: A Systematic Review of Its Action

Murti, Krisna and Zuleika, Puspa and Liberty, Iche Andriyani and Legiran, Legiran and Irfannuddin, Irfannuddin and Surono, Agus (2024) Similarity result of_Platelet‑rich Fibrin: A Systematic Review of Its Action. Turnitin Universitas Sriwijaya, Turnitin Universitas Sriwijaya. (Submitted)

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Abstract

Purpose: We aim to conduct a literature review on actions of platelet‑rich fbrin (PRF), preclinical studies in PRF utility, and its potential uses in clinical settings. Methods: We conducted a literature review based on primary studies conducted on PubMed and Europe PMC between 2012 and 2022. We included 42 articles in this review from the results of our search. Results: Epithelial tissues act as a barrier from mechanical, chemical, and temperature damage. Naturally, hemostasis acts to reduce blood loss and creates initial fbrin matrices after traumatic events or injuries. PRF is a second‑generation platelet concentrate, commonly made in the form of leukocyte and PRF due to leukocyte content. Fibrin matrices in PRF allow more sustained growth factors release when compared to PRP, the frst‑generation platelet concentrate. PRF comes from increased proliferation and differentiation mediated by reduced proliferation of inflammatory cells and sustained release of growth factors and cytokines. Conclusions: PRF action comes from increased proliferation and differentiation from growth factors and cytokines. PRF may reduce inflammation and fbrosis to improve soft‑tissue and bone healing and allow for better graft integration. Keywords: Biocompatible material, biological activity, platelet‑rich fbrin, tissue healing

Item Type:	Other
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) #3 Repository of Lecturer Academic Credit Systems (TPAK) > Articles Access for TPAK (Not Open Sources) #3 Repository of Lecturer Academic Credit Systems (TPAK) > Results of Ithenticate Plagiarism and Similarity Checker
Divisions:	04-Faculty of Medicine > 11718-Pathology Anatomy (Sp
Depositing User:	dr., Ph.D. Krisna Murti
Date Deposited:	09 Sep 2024 23:46
Last Modified:	09 Sep 2024 23:46
URI:	http://repository.unsri.ac.id/id/eprint/156937

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