HUBUNGAN KADAR SGOT DAN SGPT DENGAN DERAJAT KEPARAHAN DEMAM BERDARAH DENGUE ANAK

SINAGA, PALMA EASTER and Oktariana, Desi and Verdiansah, Verdiansah (2024) HUBUNGAN KADAR SGOT DAN SGPT DENGAN DERAJAT KEPARAHAN DEMAM BERDARAH DENGUE ANAK. Undergraduate thesis, SRIWIJAYA UNIVERSITY.

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Abstract

Demam Berdarah Dengue (DBD) merupakan penyakit infeksi yang dapat menyebabkan komplikasi serius seperti syok. Penelitian sebelumnya menunjukkan adanya peningkatan kadar enzim hati, terutama SGOT dan SGPT, pada pasien DBD, yang sering dikaitkan dengan derajat keparahan penyakit. Namun, penelitian hubungan spesifik antara kadar SGOT, SGPT, dan keparahan DBD pada anak masih terbatas. Penelitian ini bertujuan untuk menganalisis hubungan kadar SGOT dan SGPT dengan derajat keparahan DBD pada anak. Penelitian ini menggunakan desain analitik observasional dengan pendekatan cross-sectional berdasarkan data sekunder dari rekam medik dan laboratorium sentral RSUP Dr. Mohammad Hoesin Palembang periode Januari 2020 – Juni 2024. Karakteristik pasien, kadar SGOT dan SGPT, serta derajat keparahan DBD dicatat. Analisis hubungan antara kadar SGOT, SGPT, dan derajat keparahan dilakukan menggunakan uji chi-square, dilanjutkan dengan uji regresi logistik. Mayoritas pasien berusia 5-10 tahun (47,5%), dengan distribusi jenis kelamin laki-laki sedikit lebih tinggi (50,8%). Sebagian besar tidak menerima cairan sebelum dirawat (83,1%) dengan awitan demam terbanyak pada hari ke-5 demam (39%) dan lama rawat inap terbanyak ≤4 hari (62,7%). Kadar SGOT dan SGPT meningkat pada pasien dengan keparahan lebih tinggi. Analisis bivariat menunjukkan hubungan signifikan antara SGOT (p=0,027) dan SGPT (p=0,001) dengan derajat keparahan. Dengan analisis regresi logistik mennunjukkan SGPT terbukti sebagai variabel yang lebih signifikan (p=0,004). Kadar SGOT dan SGPT berhubungan dengan derajat keparahan DBD pada anak, dengan SGPT sebagai variabel paling signifikan. Pemeriksaan SGOT dan SGPT penting untuk memantau perkembangan pasien DBD dan mencegah komplikasi lebih lanjut. Kata Kunci. Demam Berdarah Dengue, SGOT, SGPT, Derajat Keparahan, Anak Dengue Hemorrhagic Fever (DHF) is an infectious disease that can cause severe complications such as shock. Previous studies have shown an increase in liver enzymes, particularly SGOT and SGPT, in DHF patients, often associated with severity of disease. However, research on specific relationship between SGOT, SGPT, and DHF severity in children is still limited. This study aims to analyze the relationship between SGOT and SGPT levels and the severity of DHF in children. This study used an observational analytic design with a cross-sectional approach based on secondary data from medical records and central laboratories in RSUP Dr. Mohammad Hoesin Palembang from January 2020 to June 2024. Patient characteristics, SGOT and SGPT levels, and DHF severity were recorded. The relationship between SGOT, SGPT, and disease severity was analyzed using logistic regression tests. The majority of patients were 5-10 years old (47,5%), with higher distribution on male (50,8%). Most had not received fluids before hospitalization (83,1%), with onset of fever was on day-5 (39%) and the most common length of stay was ≤4 days (62,7%). SGOT and SGPT levels were higher in patients with more severe conditions. Bivariate analysis showed a significant relationship between SGOT (p=0.027) and SGPT (p=0.001) with disease severity. Logistic regression analysis revealed SGPT as a more significant variable (p=0.004). In conclusion, SGOT and SGPT levels are associated with severity of DHF in children, with SGPT being a strongest variable. The SGOT and SGPT examinations are important for monitoring DHF progression and preventing further complications. Keywords. Dengue Hemorrhagic Fever, SGOT, SGPT, Severity, Children

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Demam Berdarah Dengue, SGOT, SGPT, Derajat Keparahan, Anak
Subjects:	R Medicine > RB Pathology > RB37-56.5 Clinical pathology. Laboratory technique R Medicine > RJ Pediatrics > RJ1-570 Pediatrics
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Palma Easter Sinaga
Date Deposited:	17 Dec 2024 06:43
Last Modified:	17 Dec 2024 06:43
URI:	http://repository.unsri.ac.id/id/eprint/160222

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