HUBUNGAN KELEBIHAN ZAT BESI DENGAN FUNGSI HATI PADA PASIEN ANAK THALASSEMIA BERGANTUNG TRANSFUSI DI RSUP DR. MOHAMMAD HOESIN PALEMBANG

WIJAYA, KEMAS MUHAMMAD PRATAMA PUTRA and Sari, Dian Puspita and Liana, Phey (2024) HUBUNGAN KELEBIHAN ZAT BESI DENGAN FUNGSI HATI PADA PASIEN ANAK THALASSEMIA BERGANTUNG TRANSFUSI DI RSUP DR. MOHAMMAD HOESIN PALEMBANG. Undergraduate thesis, Sriwijaya University.

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Abstract

Pediatric transfusion-dependent thalassemia patients require lifelong transfusion to compensate for inadequate erythrocyte and to support patient’s growth and development. However, regular transfusion can cause iron overload leading to oxidative stress-induced liver injury. The purpose of this study is to analyze the relationship between iron overload and liver function in pediatric transfusion-dependent thalassemia patients at RSUP Dr. Mohammad Hoesin Palembang. This study is an analytical observational study with a cross-sectional study design. This study included 139 pediatric transfusion-dependent thalassemia patients at RSUP Dr. Mohammad Hoesin Palembang aged between 1-18 years old. This study used secondary data consisting of sociodemographic characteristics, iron status, and liver function obtained from patient’s medical record. The Chi-Square and Fisher test is used to analyze the relationship between each indicator of iron status and liver function in the patients. Majority of patients have ≥ 1000 µg/L serum ferritin (88,5%), ≥ 70% transferrin saturation (68,3%), and high total bilirubin (69,8%). Most patients have normal SGOT (59,0%), SGPT (59,7%), PT (97,8%), APTT (87,8%), and albumin (97,1%). All patients have normal total protein. Iron overload has significant relationships with SGOT (p=0,003 and p=0,001) and SGOT (p=0,003 and p=0,001), but not with PT (p=0,309 and p=0,235), APTT (p=0,693 and 0,442), total bilirubin (p=0,776 dan p=0,607), and albumin (p=0,390 and p=1,000). Iron overload has significant relationships with SGOT and SGPT in pediatric transfusion-dependent thalassemia patients at RSUP Dr. Mohammad Hoesin Palembang. Kata Kunci: Thalassemia Bergantung Transfusi, Kelebihan Zat Besi, Fungsi Hati.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Thalassemia Bergantung Transfusi, Kelebihan Zat Besi, Fungsi Hati. Kepustakaan: 61
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > RB Pathology > RB37-56.5 Clinical pathology. Laboratory technique R Medicine > RJ Pediatrics > RJ1-570 Pediatrics
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Kemas Muhammad Pratama Putra Wijaya
Date Deposited:	16 Dec 2024 03:06
Last Modified:	16 Dec 2024 03:06
URI:	http://repository.unsri.ac.id/id/eprint/160311

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