PENGARUH EKSTRAK ETIL ASETAT DAUN UBI JALAR UNGU(Ipomoea batatas L.)TERHADAP MAKROSKOPIS DAN HISTOPATOLOGI HATI TIKUS WISTAR MODEL FIBROSIS HATI

RAMANDA, SAFITRIANA and Suciati, Tri and Wardiansah, Wardiansah (2024) PENGARUH EKSTRAK ETIL ASETAT DAUN UBI JALAR UNGU(Ipomoea batatas L.)TERHADAP MAKROSKOPIS DAN HISTOPATOLOGI HATI TIKUS WISTAR MODEL FIBROSIS HATI. Undergraduate thesis, Sriwijaya University.

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Abstract

Background: The liver is a vital organ essential for metabolism, detoxification,and nutrient storage but is highly vulnerable to damage from exposure to toxic substances like CCl4. This compound can rapidly induce liver fibrosis. Purple sweet potato (Ipomoea batatas L.), a plant widely consumed in Indonesia, is predominantly used for its tubers, while its leaves are often neglected. However, the leaves are rich in metabolites such as alkaloids, flavonoids, tannins, and steroid-triterpenoids, which exhibit potent antioxidant activity and potential hepatoprotective effects. Methods: The type of research conducted was experimental research in the form of in vivo with post test with control group design. This research was conducted from July to November 2024. This research was conducted in the Animal House, biochemical laboratory, and Barokah anatomical pathology special laboratory. Results: In the positive group of rats given silymarin 50 mg / kgBB and the group given ethyl acetate extract of purple sweet potato leaves at a dose of 500, and 750 mg / kgBB, it was proven that there was an improvement in liver cells in macroscopic observations and liver histopathology of Wistar rats with liver fibrosis models that were most similar to the normal group. Conclusion: The administration of ethyl acetate extract of purple sweet potato leaves to Wistar rats with liver fibrosis demonstrated macroscopic and histopathological improvements in the liver. Keywords: Ethyl Acetate Extract of Purple Sweet Potato Leaves, Liver Fibrosis, Macroscopic Liver, Liver Histopathology

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Ekstrak Etil Asetat Daun Ubi Jalar Ungu, Fibrosis hati, Makroskopis Hati, Histopatologi Hati
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Safitriana Ramanda
Date Deposited:	18 Dec 2024 02:07
Last Modified:	18 Dec 2024 02:07
URI:	http://repository.unsri.ac.id/id/eprint/160484

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