EFEKTIVITAS SUPLEMENTASI VITAMIN D TERHADAP RESPON PENGOBATAN PASIEN KARSINOMA NASOFARING YANG MENJALANI KEMOTERAPI

LEONITA, DEWANGGA and Utama, Denny Satria and Harahap, Debby Handayati (2024) EFEKTIVITAS SUPLEMENTASI VITAMIN D TERHADAP RESPON PENGOBATAN PASIEN KARSINOMA NASOFARING YANG MENJALANI KEMOTERAPI. Undergraduate thesis, Sriwijaya University.

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Abstract

Background: The current standard therapy approach for NPC is radiotherapy alone or with concurrent chemotherapy. In patients receiving chemotherapy, vitamin D is inversely correlated with the percentage of pathological complete response. This study aims to determine the effectiveness of vitamin D supplementation on therapy response in nasopharyngeal carcinoma patients with chemotherapy. Methods: A quasi-experimental study was undertaken at Dr. Mohammad Hoesin Hospital, Palembang from April to October 2024. A total of 26 samples of patients newly diagnosed with nasopharyngeal carcinoma and receiving chemotherapy who met the study criteria were obtained. The dose of vitamin D intervention was 2000 IU and the therapy response was evaluated after 3 series of chemotherapy. Results: The highest therapy response was complete response (50%), followed by partial response (23.1%) and progressive disease and stable disease each 7.7%. The therapy response of both interventions did not show significant results (p = 0.207) but complete response was more common in the chemotherapy add on vitamin D group (75%) compared to the chemotherapy group (36.4%) and progressive disease was only found in the chemotherapy group (18.2%). Conclusion: Add on supplementation of 2000 IU vitamin D in chemotherapy for 3 series has not shown significant results on therapy response in nasopharyngeal carcinoma patients with chemotherapy.

Item Type:	Thesis (Undergraduate)
Subjects:	R Medicine > RF Otorhinolaryngology > RF1-547 Otorhinolaryngology
Divisions:	04-Faculty of Medicine > 11705-Ear, Nose and Throat (Sp
Depositing User:	Dewangga Leonita
Date Deposited:	20 Dec 2024 02:43
Last Modified:	20 Dec 2024 02:43
URI:	http://repository.unsri.ac.id/id/eprint/160761

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