Similarity result of_Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study

Murti, Krisna and Harahap, Agnes Stephanie and Mutmainnah, Mutiah and Ham, Maria Francisca and Khoirunnisa, Dina and Assadyk, Abdillah Hasbi and Cangara, Husni and Asri, Aswiyanti and Retnani, Diah Prabawati and Quzwain, Fairuz and Agustina, Hasrayati and Istiadi, Hermawan and Windarti, Indri and Takbir, Muhammad and Mahastuti, Ni Made and Kurniasari, Nila and Anggorowati, Nungki and Abineno, Pamela and Setyorini, Yulita Pundewi and Kakudo, Kennichi (2024) Similarity result of_Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study. Seoul National University, Turnitin Universitas Sriwijaya. (Submitted)

Text
SIMILA~1.PDF
Download (3MB)

Official URL: https://synapse.koreamed.org/articles/1516088932

Abstract

Background: The diagnosis of thyroid neoplasms necessitates the identification of distinct histological features. Various education/hospital centers located in cities across Indonesia likely result in discordances among pathologists when diagnosing thyroid neoplasms. Methods: This study examined the concordance among Indonesian pathologists in assessing nuclear features and capsular and vascular invasion of thyroid tumors. Fifteen pathologists from different centers independently assessed the same 14 digital slides of thyroid tumor specimens. All the specimens were thyroid neoplasms with known BRAFV600E and RASmutational status, from a single center. We evaluated the pre- and post-training agreement using the Fleiss kappa. The significance of the training was evaluated using a paired T-test. Results: Baseline agreement on nuclear features was slight to fair based on a 3-point scoring system (k=0.14 to 0.28) and poor to fair based on an eight-point system (k=–0.02 to 0.24). Agreements on vascular (κ=0.35) and capsular invasion (κ=0.27) were fair, whereas the estimated molecular type showed substantial agreement (κ=0.74). Following the training, agreement using the eight-point system significantly improved (p=0.001). Conclusions: The level of concordance among Indonesian pathologists in diagnosing thyroid neoplasm was relatively poor. Consensus in pathology assessment requires ongoing collaboration and education to refine diagnostic criteria.

Item Type:	Other
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) #3 Repository of Lecturer Academic Credit Systems (TPAK) > Articles Access for TPAK (Not Open Sources) #3 Repository of Lecturer Academic Credit Systems (TPAK) > Results of Ithenticate Plagiarism and Similarity Checker
Divisions:	04-Faculty of Medicine > 11718-Pathology Anatomy (Sp
Depositing User:	dr., Ph.D. Krisna Murti
Date Deposited:	27 Dec 2024 06:17
Last Modified:	27 Dec 2024 06:17
URI:	http://repository.unsri.ac.id/id/eprint/160779

Actions (login required)

View Item