OPTIMASI DOSIS STREPTOZOTOCIN PADA TIKUS WISTAR (Rattus norvegicus) UNTUK INDUKSI DIABETES MELLITUS

ADITYA, PRIMA YUDHA and Pariyana, Pariyana and Parisa, Nita (2024) OPTIMASI DOSIS STREPTOZOTOCIN PADA TIKUS WISTAR (Rattus norvegicus) UNTUK INDUKSI DIABETES MELLITUS. Undergraduate thesis, Sriwijaya University.

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Abstract

Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels. Diabetes mellitus has become one of the major health issues with a steadily increasing prevalence in Indonesia. Due to its significant impact, diabetes mellitus has become a primary focus in the medical field. Over the years, animal experiments have been conducted to study diabetes mellitus and evaluate anti-diabetic agents. This study employed an in vivo experimental design involving 28 male Wistar rats divided into four treatment groups with different streptozotocin doses: 35, 50, 65, and 80 mg/kgBW. In this study, the diabetes mellitus animal model was induced using streptozotocin. Parameters were measured on days 0, 1, 2, 3, 7, and 14. The study revealed that streptozotocin administration resulted in weight loss and an increase in fasting and random blood glucose, particularly at doses of 50 mg/kgBW, 65 mg/kgBW, and 80 mg/kgBW. Statistical analysis demonstrated significant differences among groups with varying STZ doses in terms of changes in body weight and fasting and random blood glucose, with p<0.05. Weight loss and an increase in fasting and random blood glucose were observed in the intervention groups. Streptozotocin doses of 50 mg/kgBW can be considered optimal for developing a diabetes model in Wistar rats.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Diabetes Mellitus, Tikus Wistar, Streptozotocin, Glukosa Darah, Berat Badan.
Subjects:	R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Prima Yudha Aditya
Date Deposited:	20 Dec 2024 03:57
Last Modified:	20 Dec 2024 03:57
URI:	http://repository.unsri.ac.id/id/eprint/160975

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