PERBEDAAN ABSOLUTE LYMPHOCYTE COUNT SEBELUM DAN SESUDAH PEMBERIAN TERAPI SIKLOFOSFAMID PADA PASIEN LUPUS ERITEMATOSUS SISTEMIK ANAK

PERMATA, SITI NURUL and Novery, Edy and Fertilita, Soilia (2024) PERBEDAAN ABSOLUTE LYMPHOCYTE COUNT SEBELUM DAN SESUDAH PEMBERIAN TERAPI SIKLOFOSFAMID PADA PASIEN LUPUS ERITEMATOSUS SISTEMIK ANAK. Undergraduate thesis, Sriwijaya university.

	Text RAMA_11201_04011382126244.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_04011382126244_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (8MB) | Request a copy
	Text RAMA_11201_04011382126244_8942960023_0008108305_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (960kB)
	Text RAMA_11201_04011382126244_8942960023_0008108305_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_11201_04011382126244_8942960023_0008108305_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (344kB) | Request a copy
	Text RAMA_11201_04011382126244_8942960023_0008108305_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (318kB) | Request a copy
	Text RAMA_11201_04011382126244_8942960023_0008108305_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (189kB) | Request a copy
	Text RAMA_11201_04011382126244_8942960023_0008108305_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (155kB) | Request a copy
	Text RAMA_11201_04011382126244_8942960023_0008108305_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (818kB) | Request a copy

Abstract

Backgroud: Systemic Lupus Eritematosus (SLE) is an autoimmune condition that affects multiple organs and often induced periods of remission and relapse. One of the therapies used is cyclophosphamide. However, previous studies have shown that cyclophosphamide has side effects, including lymphopenia. Methods: This studies is an analitic observational study with a cross sectional study design. Data were taken from the medical record of pediatric SLE patients who received cyclophosphamide therapy at Dr. Mohammd Hoesin General Hospital Palembang, from January 2020 to October 2024. The sample for this study consisted 50 samples. Sampling was taken using the total sampling method. The data were processed using SPSS 27 version and analyzed with wilcoxon test. Results: In this study, there were 50 research samples. Female patients dominated the sample, with 44 participants being female. The age range of patients was between 6 and 17 years old, with a mean age of 13.4 ± 2.807 years. The mean Absolute Lymphocyte Count (ALC) before therapy was 1,557.54 cells/mm3 and after therapy, it was 1,347.58 cells/mm3. There was an increase in the number of patients with lymphopenia due to cyclophosphamide administration, and a decreased in the mean Absolute Lymphocyte Count (ALC) before and after therapy during the three-months observation period, but it was not statistically significant. Conclusion: There was no significant difference in ALC; however, a decrease in the median ALC was observed before and after three months of cyclophosphamide therapy in pediatric SLE patients at Dr. Mohammad Hoesin General Hospital, Palembang, during the period of January 2020 to October 2024.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Absolute Lymphocyte Count (ALC), Children, Cyclophosphamide, Systemic Lupus Erythematosus.
Subjects:	R Medicine > RJ Pediatrics > RJ1-570 Pediatrics
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Siti Nurul Permata
Date Deposited:	24 Dec 2024 02:28
Last Modified:	24 Dec 2024 02:28
URI:	http://repository.unsri.ac.id/id/eprint/161290

Actions (login required)

View Item