DISTRIBUSI JENIS BAKTERI DAN HASIL SENSITIVITAS ANTIBIOTIK BERDASARKAN HASIL KULTUR DARAH PADA PASIEN SEPSIS DI ICU RSMH TAHUN 2022 - 2023

SARAGIH, PUTRI MEILISA and Lestari, Mayang Indah and Nawawi, Rizki Andini (2024) DISTRIBUSI JENIS BAKTERI DAN HASIL SENSITIVITAS ANTIBIOTIK BERDASARKAN HASIL KULTUR DARAH PADA PASIEN SEPSIS DI ICU RSMH TAHUN 2022 - 2023. Undergraduate thesis, Sriwijaya University.

	Text RAMA_11201_04011282126098.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (62MB) | Request a copy
	Text RAMA_11201_04011282126098_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (7MB) | Request a copy
	Text RAMA_11201_04011282126098_0025098503_8911240022_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (17MB)
	Text RAMA_11201_04011282126098_0025098503_8911240022_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (17MB) | Request a copy
	Text RAMA_11201_04011282126098_0025098503_8911240022_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_11201_04011282126098_0025098503_8911240022_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (13MB) | Request a copy
	Text RAMA_11201_04011282126098_0025098503_8911240022_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_11201_04011282126098_0025098503_8911240022_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy
	Text RAMA_11201_04011282126098_0025098503_8911240022_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (9MB) | Request a copy

Abstract

Sepsis is a life-threatening condition that occurs when the body’s immune system fails to respond properly to an infection, leading to organ dysfunction. It remains a significant global health issue, particularly in low- and middle-income countries. This study aimed to examine the distribution of bacterial types and their antibiotic sensitivity patterns in blood cultures from sepsis patients. Using a retrospective descriptive design, we analyzed blood culture data from sepsis patients treated in the ICU at RSMH Palembang. A total of 14 samples were included in this study. The majority of sepsis patients were adults or pre-elderly, with an equal distribution of men and women. Diabetes was the most common comorbidity, seen in 42.9% of cases, and the median length of stay in the hospital was 5.5 days. Among the Gram-positive bacteria, Coagulase-negative Staphylococci (CoNS) were the most frequently identified, while Escherichia coli, Klebsiella pneumoniae ssp pneumoniae, and Acinetobacter baumannii were the dominant Gram-negative bacteria. Linezolid, nitrofurantoin, and vancomycin were the most effective antibiotics against gram-positive bacteria, while amikacin, ertapenem, gentamicin, meropenem, nitrofurantoin, piperacillin-tazobactam, and sulfamethoxazole-trimethoprim showed good sensitivity against gram-negative bacteria. Interestingly, tigecycline was found to be effective against both gram-positive and gram-negative bacteria. Penicillin-class antibiotics displayed the highest resistance against Gram-positive bacteria. Additionally, this study identified Extended-Spectrum-Beta-Lactamase (ESBL) producing bacteria and Methicillin-Resistant Staphylococcus aureus (MRSA) as multidrug-resistant organisms (MDROs). In conclusion, Coagulase-negative Staphylococci (CoNS) and Escherichia coli were the most common bacteria causing sepsis in this sample. Linezolid, nitrofurantoin, and vancomycin were the most effective antibiotics for Gram-positive infections.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Kultur Darah, Distribusi Bakteri, Sensitivitas Antibiotik, Sepsis
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > RC Internal medicine > RC86-88.9 Medical emergencies. Critical care. Intensive care. First aid R Medicine > RM Therapeutics. Pharmacology > RM265-267 Antibiotic therapy. Antibiotics
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Putri Meilisa Saragih
Date Deposited:	27 Dec 2024 02:50
Last Modified:	27 Dec 2024 02:50
URI:	http://repository.unsri.ac.id/id/eprint/161585

Actions (login required)

View Item