AL GHAZY, HAIKAL BECCARIA and Murti, Krisna and Handayani, Dwi (2024) HUBUNGAN RASIO TROMBOSIT-LIMFOSIT PRATERAPI DENGAN PROGNOSIS PASIEN DIFFUSE LARGE B CELL LYMPHOMA DI RSUP DR. MOHAMMAD HOESIN PALEMBANG. Undergraduate thesis, Sriwijaya University.
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Abstract
Diffuse large B cell lymphoma (DLBCL) is a subtype of non-Hodgkin lymphoma (NHL) characterized by large B lymphoid cells, where the nucleus exceeds the size of a normal lymphocyte nucleus, exhibiting a spectrum of cellular progenitors and consistent nuclear morphology. Platelets and lymphocytes are commonly assessed to predict the prognosis of DLBCL patients. The platelet-to-lymphocyte ratio (PLR) has emerged as a novel prognostic marker, as this ratio represents the combined concept of platelet activity and inflammatory pathways, both of which play a role in the pathogenesis of malignancy. The aim of this study is to examine the correlation between the pre-treatment platelet-to-lymphocyte ratio and the prognosis of DLBCL patients. This study is an analytical observational with a retrospective cohort design, accompanied by survival analysis. The sample for this study consists of DLBCL patients from Dr. Mohammad Hoesin General Hospital Palembang in 2020–2023, who meet the inclusion criteria and were selected using consecutive sampling technique. The data will be analyzed using ROC curve, Kaplan-Meier curve, Mantel-Cox test, Cox regression, and time-independent Cox regression. The ROC curve analysis determined cut-off point of platelet-lymphocyte ratio was 193,1 with 70,4% in sensitivity and 69,2% in specificity. Based on the Kaplan-Meier curve analysis yielded a median overall survival was 0.58 years and the variables that met the proportional hazards assumption were stage and platelet-to-lymphocyte ratio. The results of the bivariate analysis showed a p-value for stage was <0.001 and a p-value for the platelet-to-lymphocyte ratio was 0.022. The results of the multivariate analysis showed a p-value for stage was <0.001 and a p-value for the platelet-to-lymphocyte ratio was 0.155. Stage and platelet-to-lymphocyte ratio are significantly correlated with overall survival with stage being the most strongly correlated factor.
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Uncontrolled Keywords: | DLBCL, Platelet-Lymphocyte Ratio, Prognosis, Overall Survival |
| Subjects: | R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > RB Pathology > RB1-214 Pathology R Medicine > RB Pathology > RB151-214 Theories of disease. Etiology. Pathogenesis R Medicine > RB Pathology > RB24-33 Pathological anatomy and histology R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RC Internal medicine > RC633-647.5 Diseases of the blood and blood-forming organs R Medicine > RC Internal medicine > RC71-78.7 Examination. Diagnosis. Including radiography R Medicine > RD Surgery > RD651-678 Neoplasms. Tumors. Oncology |
| Divisions: | 04-Faculty of Medicine > 11201-Medicine (S1) |
| Depositing User: | Haikal Beccaria Al Ghazy |
| Date Deposited: | 27 Dec 2024 07:13 |
| Last Modified: | 27 Dec 2024 07:13 |
| URI: | http://repository.unsri.ac.id/id/eprint/161760 |
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