UJI AKTIVITAS PENYEMBUHAN LUKA BAKAR DAN LUKA SAYAT DARI EKSTRAK ETANOL DAUN PACAR KUKU (Lawsonia inermis L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR

PUTRI, DISWITA AMILIA and Muharni, Muharni and Amriani S, Annisa (2025) UJI AKTIVITAS PENYEMBUHAN LUKA BAKAR DAN LUKA SAYAT DARI EKSTRAK ETANOL DAUN PACAR KUKU (Lawsonia inermis L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR. Undergraduate thesis, Sriwijaya University.

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Abstract

Lawsonia inermis is a traditional medicinal plant used to treat inflammation of the finger joints and skin diseases.The aims of This study were evaluated the efficacy of Lawsonia inermis leaf extract in healing burn and incision wounds. The extraction was carried out using the maceration method with ethanol solvent.The research were used 60 male Wistar rats, divided into six treatment groups (five rats per group): positive control (1% silver sulfadiazine ointment), negative control and four treatment groups with ointment concentrations of 2.5%, 5%, 7.5%, and 10% containing adeps lanae and white petrolatum. Burn wounds were created using a heated metal plate, while incision wounds were made with a sterile scalpel 3 cm in length. Observed parameters included burn area, incision length, percentage of healing, and skin histopathology.The results showed that the treatment group concentration was the most effective concentration, achieving 100% healing for burn wounds within 12 days, and the 2.5% concentration achieved 100% healing for incision wounds within 5 days. The treatment groups showed significantly different (p<0.05) wound-healing activity compared to the negative control but no significant difference (p>0.05) compared to the positive control. Histopathological analysis showed epithelial thickness of 45.54 µm and collagen thickness of 607.09 µm for burn wounds, while for incision wounds with 5% concentration, the epithelial thickness was 65.02 µm and collagen thickness 828.03 µm negative control: 16.76 µm and 350.14 µm).This data indicated the ethanol extract of Lawsonia inermis leaves at a 5% concentration can accelerate the healing of burn and incision wounds.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Lawsonia inermis, Luka bakar, luka sayat, Histopatologi kulit
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Diswita Amilia Putri
Date Deposited:	13 Jan 2025 04:32
Last Modified:	13 Jan 2025 04:32
URI:	http://repository.unsri.ac.id/id/eprint/163840

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