Partan, Radiyati Umi (2018) Reviewer_2_Radiyati_Umi_Partan_The Efficacy of Seluang Fish (Rasbora argryotaenia) Oil in Cognitive Function and Expression of Brain-Derived Neurotrophic Factor(BDNF) in Rattus norvegicusStrain Wistar. Research Journal of Pharmaceutical, Biological and Chemical Sciences, Fakultas Kedokteran Universitas Sriwijaya.
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Abstract
Rasbora argryotaenia (Seluang fish) is freshwater fish, has oily skin and slim body. Fish oil contain omega-3, EPA and DHA. Omega-3 has a potential to increase expression of BDNF and restoration cognitive function. An experimental research design, eight-week-old male Wistar Rat (n = 28) were randomized into four groups, and each group consisted of 7 rats. Normal control group, group 2,3 and 4 : rats were induced by seluang fish oil 0,1 mL/kgBW, 0,2 mL/kgBW and 0,4 mL/kgBW for 21 days. Cognitive function was assayed by eight-arm maze test. Concentration of BDNF in hippocampus was assayed by ELISA. Eight-arm maze test and concentration of BDNF in group 1 (600 second, 163,65pg/mL); group 2 (459 second, 168,25pg/mL); group 3 (298 second, 234,63pg/mL); group 4 (163 second, 270,45pg/mL). Seluang fish oil at doses 0,2 mL/kgBW and 0,4 mg/kgBW had efficacy to restore cognitive function via increased concentration of BDNF in hippocampus area.Keywords:Seluang Fish Oil –Omega 3 –Cognitive –Eight Arm Maze Test –BDNF
| Item Type: | Other |
|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC581-951 Specialties of internal medicine |
| Divisions: | 04-Faculty of Medicine > 11702-Internal Medicine (Sp |
| Depositing User: | dr radiyati umi partan |
| Date Deposited: | 18 Nov 2019 03:05 |
| Last Modified: | 18 Nov 2019 03:05 |
| URI: | http://repository.unsri.ac.id/id/eprint/16623 |
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