UJI AKTIVITAS ANTIHIPERURISEMIA FRAKSI ETIL ASETAT DAUN NANGKA (ARTOCARPUS HETEROPHYLLUS) PADA TIKUS JANTAN GALUR WISTAR

ANGGRAINI, SHELLA and Muharni, Muharni and Amriani, Annisa (2025) UJI AKTIVITAS ANTIHIPERURISEMIA FRAKSI ETIL ASETAT DAUN NANGKA (ARTOCARPUS HETEROPHYLLUS) PADA TIKUS JANTAN GALUR WISTAR. Undergraduate thesis, Sriwijaya University.

	Text RAMA_48201_08061382126105.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_48201_08061382126106_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy
	Text RAMA_48201_08061382126106_0004036903_0029128405_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (789kB)
	Text RAMA_48201_08061382126106_0004036903_0029128405_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (336kB) | Request a copy
	Text RAMA_48201_08061382126106_0004036903_0029128405_03.pdf - Accepted Version Restricted to Repository staff only Download (343kB) | Request a copy
	Text RAMA_48201_08061382126106_0004036903_0029128405_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (396kB) | Request a copy
	Text RAMA_48201_08061382126105_0004036903_0029128405_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (238kB) | Request a copy
	Text RAMA_48201_08061382126105_0004036903_0029128405_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (276kB) | Request a copy
	Text RAMA_48201_08061382126105_0004036903_0029128405_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy

Abstract

Jackfruit leaves (A. heterophyllus) contain flavonoid compounds that are active as anti-inflammatory. Anti-inflammatory is related to antihyperuricemia. This study aims to evaluate the antihyperuricemia activity of the ethyl acetate fraction of jackfruit leaves in male white rats of the Wistar strain. The ethyl acetate fraction was obtained from extraction by a cascading maceration method starting from n-hexane solvent followed by ethyl acetate solvent. For the ethyl acetate fraction, the extract was standardized and antihyperuricemia activity was tested using 35 mice consisting of 7 groups, namely the normal group, the negative control group (Na-CMC), the positive control group (allopurinol), and the treatment group with doses of 100 mg/kgBB (P1), 200 mg/kgBB (P2), 400 mg/kgBB (P3), and 800 mg/kgBB (P4). To get hyperuricemia, rats were given chicken liver juice and purine rich melinjo seeds. Uric acid level measurements were carried out on days 0, 15, 20, 25, and 30. The standardization results showed that the ethyl acetate fraction of jackfruit leaves met the parameters of the extract requirements. The results of the antihyperuricemia test f ethyl acetate action showed antihyperuricemia activity and the highest activity was shown by the treatment of a dose of 800 mg/kg BB with a % decrease in acid content of 79.37%. For positive control, allopurinol provides antihyperuricemia activity with a % decrease in uric acid levels of 90.72%. Statistical analysis showed that there was no significant difference (P > 0.05) between the 100 and 200 mg/kg BB dose treatment but there was a significant difference (P < 0.05) with the 400 and 800 mg/kg BB dose treatment. The analysis also showed that there was a significant difference between the treatment dose of 800 mg/kg BB and the allopurinol-positive control group. The ethyl acetate fraction showed an effective dose value (ED50) of 348,598 mg/kgBB. This data shows that the ethyl acetate fraction of jackfruit leaves has the potential to be developed as a source of raw materials for uric acid

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Artocarpus heterophyllus, Antihyperuricemia, Ethyl acetate fraction
Subjects:	E History America > E171-183.9 History Q Science > QM Human anatomy Q Science > QM Human anatomy > QM531-549 Regional anatomy Q Science > QM Human anatomy > QM550-577.8 Human and comparative histology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Shella Anggraini
Date Deposited:	23 Jan 2025 02:47
Last Modified:	23 Jan 2025 02:47
URI:	http://repository.unsri.ac.id/id/eprint/166435

Actions (login required)

View Item