UJI ANALGETIKA DAN ANTIINFLAMASI EKSTRAK DAN FRAKSI DAUN KARDIA (Bellucia pentamera Naudin) TERHADAP TIKUS WISTAR JANTAN

AMELIA, AYU and Salni, Salni and Fitrya, Fitrya (2025) UJI ANALGETIKA DAN ANTIINFLAMASI EKSTRAK DAN FRAKSI DAUN KARDIA (Bellucia pentamera Naudin) TERHADAP TIKUS WISTAR JANTAN. Undergraduate thesis, Universitas Sriwijaya.

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Abstract

The Kardia plant (Bellucia Pentamera Naudin), a member of the Melastomataceae family, contains compounds such as steroids, triterpenoids, and flavonoids, which exhibit potential analgesic and anti-inflammatory properties. This study aims to characterize the extract and evaluate its analgesic and anti-inflammatory effects based on the reduction in writhing behavior in mice and edema volume in rats treated with extracts and fractions of Kardia leaves. The analgesic and anti-inflammatory tests were conducted using the writhing test and rat hind paw edema method on 24 male Wistar rats, divided into six groups: a positive control group treated with sodium diclofenac, a negative control group treated with 1% Na CMC, and test groups (ethanol extract, n-hexane fraction, ethyl acetate fraction, and ethanol-water fraction) at a dose of 400 mg/kg body weight. The highest analgesic and anti-inflammatory activity was observed in the n-hexane fraction, which contained triterpenoid and steroid compounds. The highest analgesic percentage was recorded in the n-hexane fraction (73.74%), followed by the ethyl acetate fraction (71.74%), ethanol extract (67.99%), and ethanol-water fraction (64.16%). The n-hexane fraction group showed no significant difference compared to the positive control group (72.44%). The highest anti-inflammatory inhibition percentage was also observed in the n-hexane fraction group (51.20%), followed by the ethyl acetate fraction (50.44%), ethanol extract (50.00%), and ethanol-water fraction (41.00%). The n-hexane fraction group showed no significant difference compared to the positive control group (61.00%). Key words: Bellucia pentamera Naudin, analgesics, anti-inflammatory, writhing test, rat hind paw edema

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Inflamasi
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Ayu Amelia
Date Deposited:	05 Mar 2025 04:17
Last Modified:	05 Mar 2025 04:17
URI:	http://repository.unsri.ac.id/id/eprint/167910

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