UJI AKTIVITAS NANOEMULSI MINYAK CENGKEH DAN CREMOPHOR RH-40 PEMBAWA ASAM USNAT TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS WISTAR

AYUDHIA, PUTRI and Amriani, Annisa and Agustiarini, Vitri (2025) UJI AKTIVITAS NANOEMULSI MINYAK CENGKEH DAN CREMOPHOR RH-40 PEMBAWA ASAM USNAT TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS WISTAR. Undergraduate thesis, Sriwijaya University.

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Abstract

Lichen is one of the organisms known for its diverse secondary metabolites, one of which is usnic acid. Usnic acid is known to have anti-inflammatory and antibacterial activities to accelerate burn wound healing. This study aims to determine the concentration of clove oil and Cremophor RH-40 from various concentrations to obtain the optimum usnic acid nanoemulsion formula and test its activity in healing burns. The nanoemulsion formula was optimized using the regularar two-level factorial design method analysed with Design Expert 12 software. The optimum formula selected came from the system with a concentration of 3,5% clove oil 10% Cremophor RH-40. Characterization results showed that the formula had a particle size of 223,9 ± 58,18 nm, polydispersity index of 0,37 ± 00,06, and zeta potential 0f -12,67 ± 0,15 mV. Based on data analysis using one-way ANOVA, the results showed that the optimum nanoemulsion formula did not have a significant difference compared to the positive control in burn wound healing activity as evidenced by the recovery percentage of 98,63 ± 0,1% in 12 days. Nanoemulsion has the potential to be developed as a wound healing drug. Keywords: Usnic acid, Cremophor RH-40, Burns, Clove oil, Nanoemulsion

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Asam Usnat, Cremophor RH-40, Luka Bakar, Minyak cengkeh, Nanoemulsi
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Putri Ayudhia
Date Deposited:	17 Mar 2025 06:35
Last Modified:	17 Mar 2025 06:35
URI:	http://repository.unsri.ac.id/id/eprint/169044

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