UJI IN SILICO EKSTRAK ETANOL KULIT BUAH DELIMA MERAH (Punica granatum L.) YANG BERKAITAN DENGAN HIPERPIGMENTASI SERTA UJI ANTIOKSIDAN

SALSABILLA, SALSABILLA and Shiyan, Shaum and Syarif, Nirwan (2025) UJI IN SILICO EKSTRAK ETANOL KULIT BUAH DELIMA MERAH (Punica granatum L.) YANG BERKAITAN DENGAN HIPERPIGMENTASI SERTA UJI ANTIOKSIDAN. Undergraduate thesis, Sriwijaya University.

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Abstract

Skin hyperpigmentation occurs due to excessive melanin production, causing certain areas to be darker than the surrounding skin. The use of anti-hyperpigmentation agents such as kojic acid and hydroquinone that work by inhibiting the tyrosinase enzyme can cause to serious side effects. Therefore, safer natural alternatives are needed. This study analyzes the potential of ethanol extract of red pomegranate peel (Punica granatum L.) in related to hyperpigmentation through the In Silico tests with network pharmacology and molecular docking approaches, as well as antioxidant test using the DPPH method. The results of network pharmacology analysis obtained six main proteins in regulation related to hyperpigmentation, namely EGFR, AKT1, FGF2, STAT3, SRC, and TP53. Potential compounds, namely kaempferol, ellagic acid, gallic acid, and oleamide could potentially interact with these proteins. The main signaling pathways, which are involved include PI3K-akt signaling pathway, the MAPK signaling pathway, and the FoxO signaling pathway. The molecular docking results showed that ellagic acid has the highest affinity to AKT1 (binding affinity -10.55 kcal/mol), which is characterized by the presence of hydrogen and hydrophobic bonds on the active side of the protein. The antioxidant activity of the extract showed an IC50 value of 109.503 ppm, classified as a moderate antioxidant category. These results confirm the potential of ethanol extract of red pomegranate peel as a natural antihyperpigmentation agent.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Hiperpigmentasi, kulit buah delima merah, network pharmacology, molecular docking, antioksidan
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) R Medicine > RS Pharmacy and materia medica > RS189-190 Assay methods. Standardization. Analysis
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Salsabilla Salsabilla
Date Deposited:	18 Mar 2025 06:31
Last Modified:	18 Mar 2025 06:31
URI:	http://repository.unsri.ac.id/id/eprint/169222

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