UJI POTENSI HEMOSTASIS EKSTRAK ETANOL DAUN KECAPI (SANDORICUM KOETJAPE (BURM.F.MERR.) TERHADAP MENCIT JANTAN (MUS MUSCULUS)

MUJAHIDAH, AISYAH and Lamin, Syafrina and Starlista, Viva (2025) UJI POTENSI HEMOSTASIS EKSTRAK ETANOL DAUN KECAPI (SANDORICUM KOETJAPE (BURM.F.MERR.) TERHADAP MENCIT JANTAN (MUS MUSCULUS). Undergraduate thesis, Sriwijaya University.

Preview	Image RAMA_48201_08061382126102_cover.jpg - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (334kB) | Preview
	Text RAMA_48201_08061382126102.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_48201_08061382126102_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy
	Text RAMA_48201_08061382126102_0011116214_0027049502_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (908kB)
	Text RAMA_48201_08061382126102_0011116214_0027049502_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (461kB) | Request a copy
	Text RAMA_48201_08061382126102_0011116214_0027049502_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (229kB) | Request a copy
	Text RAMA_48201_08061382126102_0011116214_0027049502_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (263kB) | Request a copy
	Text RAMA_48201_08061382126102_0011116214_0027049502_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (46kB) | Request a copy
	Text RAMA_48201_08061382126102_0011116214_0027049502_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (361kB) | Request a copy
	Text RAMA_48201_08061382126102_0011116214_0027049502_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy

Abstract

Kecapi (Sandoricum koetjape) leaves contain flavonoids, tannins, and saponins that have potential as hemostatic agents. This study aims to determine the effect of ethanol extract of kecapi leaves on bleeding time and clotting time in mice (Mus musculus) and its effective dose. This study was divided into 5 groups, namely negative control (NaCMC 1%), positive control (tranexamic acid), and extracts with doses of 100 mg/kgBB, 200 mg/kgBB, and 300 mg/kgBB. This study observed blood stopping time with the duke method and blood clotting time with the slide method. The results showed that the extract could accelerate hemostasis time significantly (p < 0.05), with a dose of 200 mg/kgBB showing effectiveness close to the positive control. The hemostasis mechanism of this extract is thought to be related to platelet activation by flavonoids, as well as tannins and saponins which act as vasoconstrictors and blood protein binders. This study suggests that ethanol extract of kecapi leaves has potential as a natural hemostatic agent.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Hemostasis, daun kecapi, waktu pembekuan darah, waktu perdarahan, metode duke dan metode slide.
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Aisyah Mujahidah
Date Deposited:	19 Mar 2025 04:54
Last Modified:	19 Mar 2025 04:54
URI:	http://repository.unsri.ac.id/id/eprint/169250

Actions (login required)

View Item