HUBUNGAN RASIO NEUTROFIL-LIMFOSIT, RASIO NEUTROFIL-MONOSIT, RASIO PLATELET-LIMFOSIT, DAN SYSTEMIC IMMUNE-INFLAMMATION INDEX TERHADAP DERAJAT KEPARAHAN PSORIASIS VULGARIS

RAHMANDA, M. REZI and Diba, Sarah and Thaha, M. Athuf and Harahap, Debby Handayati (2025) HUBUNGAN RASIO NEUTROFIL-LIMFOSIT, RASIO NEUTROFIL-MONOSIT, RASIO PLATELET-LIMFOSIT, DAN SYSTEMIC IMMUNE-INFLAMMATION INDEX TERHADAP DERAJAT KEPARAHAN PSORIASIS VULGARIS. Masters thesis, Sriwijaya University.

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Abstract

Background: Psoriasis vulgaris (PsV) is a common dermatological condition with varying degrees of severity. The Psoriasis Area and Severity Index (PASI) is the most frequently used to measure PsV severity. However, PASI assessment requires trained evaluators and is time-consuming in clinical practice, and not systemic involvement. Advances in the understanding of inflammation's role in PsV pathogenesis have contributed to the development of systemic inflammatory biomarkers derived from complete blood count (CBC) parameters to determine PsV severity. Objective: This study aims to investigate the association between the neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) with PsV severity. Methods: This was a retrospective analytical observational study with a cross-sectional design conducted at RSMH Palembang from January 2020 to December 2024. A total of 129 samples accounting with a total sampling method. PsV severity was categorized into mild and moderate-severe groups based on PASI scores. Systemic inflammatory biomarkers, including NLR, NMR, PLR, and SII, were obtained from CBC laboratory results. Results: There are significant differences in NLR, PLR, NMR, and SII with severity of PsV to cut-off value 2,74 (Sn: 71,6%; Sp: 75,8%), 148,5(Sn: 65,7%; Sp: 69,4%), 9,00 (Sn: 61,2%; Sp: 66,1%), and 962,5 (Sn: 70,1%; Sp: 79,0%), respectively. Systemic immune-inflammation index as the most significant predictor of PsV severity (p= 0.000). Subgroup analysis revealed that NLR (p= 0.018) and SII (p= 0.000) were significantly associated with hypertension in PsV patients, with 2.5-fold and 3.9-fold increased risks, and moderate-severe PsV were significantly associated with risks of 4.7-fold and 5.4-fold. Conclusion: Systemic inflammatory biomarkers, including NLR, NMR, PLR, and SII, serve as potential indicators for assessing PsV severity. Among these, SII emerges as the most influential biomarker in determining PsV severity with comorbidities. Additionally, NLR and SII are significantly associated with hypertension in the moderate-severe PsV group. Keywords: psoriasis vulgaris, Psoriasis Area and Severity Index, systemic inflammatory biomarkers, neutrophil-to-lymphocyte ratio, neutrophil-to-monocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	psoriasis vulgaris, Psoriasis Area and Severity Index, penanda inflamasi sistemik, rasio neutrofil-limfosit, rasio neutrofil-monosit, rasio platelet-limfosit, systemic immune-inflammation index
Subjects:	R Medicine > RL Dermatology > RL1-803 Dermatology R Medicine > RL Dermatology > RL110-120 Therapeutics R Medicine > RL Dermatology > RL201-331 Hyperemias, inflammations, and infections of the skin
Divisions:	04-Faculty of Medicine > 11704-Dermatology and Venereology (Sp
Depositing User:	M. REZI RAHMANDA
Date Deposited:	20 Mar 2025 06:22
Last Modified:	20 Mar 2025 06:22
URI:	http://repository.unsri.ac.id/id/eprint/169306

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