UJI STABILITAS DAN PENETRASI SERUM TRANSFERSOM EKSTRAK ETANOL 96% KULIT BAWANG MERAH (ALLIUM CEPA)

FATHURRAHMAN, WIJDAN and Wijaya, Dina Permata and Fithri, Najma Annuria (2025) UJI STABILITAS DAN PENETRASI SERUM TRANSFERSOM EKSTRAK ETANOL 96% KULIT BAWANG MERAH (ALLIUM CEPA). Undergraduate thesis, Sriwijaya University.

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Abstract

This study aims to evaluate the stability and penetration of transfersome serum formulated with 96% ethanol extract of red onion skin (Allium cepa). The results of this research are expected to serve as a foundation for developing pharmaceutical products based on natural ingredients for hair care. Red onion skin (Allium cepa) extract contains secondary metabolite compounds, specifically quercetin, which has potential as an antioxidant and stimulator of hair follicle regeneration, but has limitations due to its stability and skin penetration To enhance the delivery of the active compound into the skin, a transfersome system incorporating tween 80 and phospholipon 90G was utilized. Stability testing was conducted following the ICH Q1A(R2) guidelines through accelerated, intermediate, and long-term stability test, along with cycling tests to evaluate the effects of storage temperature fluctuations. The pH stability was also assessed to determine the optimal conditions for the formulation in its liquid state. The results indicated that transfersome serum was more susceptible to degradation than conventional serum, with degradation kinetics following a second-order reaction and a shelf life of approximately 63 days. In vitro penetration testing using a Franz diffusion cell (FDC) with rat skin membrane demonstrated that the transfersome serum exhibited a higher penetration rate than the non-transfersome serum. Kinetic release analysis revealed that the release mechanism followed the Korsmeyer-Peppas model with anomalous transport diffusion. The flux value of the transfersome serum was 0.0037 mg/cm² per hour, which was significantly higher than the flux of the non-transfersome serum at 0.0022 mg/cm² per hour. In conclusion, the formulation of transfersome serum enhances quercetin penetration but the stability requires improvement through formulation modifications.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	transfersom, uji stabilitas, uji penetrasi
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Wijdan Fathurrahman
Date Deposited:	20 Mar 2025 02:36
Last Modified:	20 Mar 2025 02:36
URI:	http://repository.unsri.ac.id/id/eprint/169484

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