EFEKTIVITAS ANTIBAKTERI KITOSAN CANGKANG KEPITING BAKAU (Scylla serrata) TERHADAP PERTUMBUHAN PORPHYROMONAS GINGIVALIS

RAMADHAN, MUHAMMAD RIZKY and Negara, Mellani Cindera and Trisnawaty K., Trisnawaty K. (2025) EFEKTIVITAS ANTIBAKTERI KITOSAN CANGKANG KEPITING BAKAU (Scylla serrata) TERHADAP PERTUMBUHAN PORPHYROMONAS GINGIVALIS. Undergraduate thesis, Sriwijaya University.

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Abstract

Background: Porphyromonas gingivalis was a pathogenic bacterium that played a role in the development of periodontal diseases, such as periodontitis. Effective treatment to inhibit the growth of this bacterium was highly needed. Chitosan, a biopolymer extracted from the shell of the mud crab (Scylla serrata), was known to have potential antibacterial properties. Objective: The aim of the study was to determine the antibacterial effectiveness of chitosan derived from the shell of the mud crab (Scylla serrata) at concentrations of 0.25%, 0.5%, and 1% against the growth of Porphyromonas gingivalis. Methods: This study was an in vitro laboratory investigation. Chitosan was extracted using the deacetylation technique from chitin isolated from the shell of the mud crab. The antibacterial effectiveness against Porphyromonas gingivalis was evaluated using the Kirby-Bauer disk diffusion method with chitosan concentrations of 0.25%, 0.5%, and 1% to measure the diameter of the inhibition zone. The positive control used in this study was 0.2% chlorhexidine. Results: Chitosan exhibited significant antibacterial activity against Porphyromonas gingivalis, with the inhibition zone increasing as the chitosan concentration increased. This indicated the potential of chitosan as an effective natural antibacterial agent in controlling bacterial infections associated with periodontal disease. Conclusion: Chitosan derived from the shell of the mud crab (Scylla serrata) had antibacterial effects against Porphyromonas gingivalis. Keywords: antibacterial, chitosan mangrove crab, periodontal disease, Porphyromonas gingivalis

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	antibakteri, kepiting bakau, kitosan, penyakit periodontal, porphyromonas gingivalis
Subjects:	R Medicine > RK Dentistry > RK1-715 Dentistry R Medicine > RK Dentistry > RK301-493 Oral and dental medicine. Pathology. Diseases
Divisions:	04-Faculty of Medicine > 12201-Dentistry (S1)
Depositing User:	Muhammad Rizky Ramadhan
Date Deposited:	25 Mar 2025 02:09
Last Modified:	25 Mar 2025 02:10
URI:	http://repository.unsri.ac.id/id/eprint/169857

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