PERBANDINGAN ANOGENITAL DISTANCE (AGD), ULTRASONOGRAFI (USG) DAN KADAR SERUM CANCER ANTIGEN - 125 (CA-125) SEBAGAI PENANDA ENDOMETRIOSIS DI RSUP DR. MOH. HOESIN PALEMBANG

RAFDI, ABI and Abadi, Adnan and Effendi, Kms Yusuf and Legiran, Legiran (2025) PERBANDINGAN ANOGENITAL DISTANCE (AGD), ULTRASONOGRAFI (USG) DAN KADAR SERUM CANCER ANTIGEN - 125 (CA-125) SEBAGAI PENANDA ENDOMETRIOSIS DI RSUP DR. MOH. HOESIN PALEMBANG. Undergraduate thesis, Sriwijaya University.

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Abstract

Background: Endometriosis is a common gynecological disease that frequently causes chronic pelvic pain and infertility. Definitive diagnosis often requires invasive surgical procedures. Therefore, non-invasive markers such as anogenital distance (AGD), ultrasonography (USG), and CA-125 levels are needed to support diagnostic accuracy.. Methods: This case-control study included 56 reproductive-age women presenting to the Obstetrics and Gynecology Outpatient Clinic at Dr. Moh. Hoesin General Hospital Palembang between November 2024 and April 2025. Subjects were divided into endometriosis (n=28) and non-endometriosis (n=28) groups. AGD was measured using a digital caliper, USG was performed by an experienced sonographer, and serum CA-125 was measured using an immunoassay method. Diagnosis was confirmed via histopathology results. Results: Mean AGD-AC and AGD-AF measurements showed no significant difference between groups (AGD-AC: 65.65±8.42 mm vs. 66.42±15.88 mm; AGD-AF: 26.27±7.65 mm vs. 26.99±7.68 mm; p>0.05). USG demonstrated a sensitivity of 78.6% and specificity of 92.9%. CA-125 levels were significantly higher in the endometriosis group (160.67±243.28 IU/mL; p=0.04) with a sensitivity of 89.3% and specificity of 82.1% at a cut-off value of 30.7 ng/mL. Conclusion: USG is effective in detecting endometriosis, and CA-125 may serve as a complementary biomarker. AGD was not shown to be a significant diagnostic marker in this study. Keywords: Endometriosis, AGD, USG, CA-125, Diagnosis

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Kedokteran, Obstetri dan Ginekologi
Subjects:	R Medicine > RG Gynecology and obstetrics > RG104-104.7 Operative gynecology R Medicine > RG Gynecology and obstetrics > RG159-208 Functional and systemic disorders. Endocrine gynecology
Divisions:	04-Faculty of Medicine > 11708-Obstetric and Gynecology (Sp
Depositing User:	Abi Rafdi
Date Deposited:	09 May 2025 04:51
Last Modified:	09 May 2025 04:51
URI:	http://repository.unsri.ac.id/id/eprint/171739

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