HUBUNGAN EKSPRESI MRNA NERVE GROWTH FACTOR DENGAN TINGKAT NYERI DAN DERAJAT KEPARAHAN ENDOMETRIOSIS

OCTARINA, BERTHA and Abadi, Adnan and Hidayat, Syarief Taufik and Zulkarnain, Iskandar and Saleh, Irsan and Theodorus, Theodorus (2025) HUBUNGAN EKSPRESI MRNA NERVE GROWTH FACTOR DENGAN TINGKAT NYERI DAN DERAJAT KEPARAHAN ENDOMETRIOSIS. Other thesis, Sriwijaya University.

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Abstract

Abstrak Tujuan: Menganalisis hubungan antara ekspresi mRNA gen NGF dengan tingkat nyeri dan keparahan endometriosis. Metode: Penelitian ini melibatkan 30 pasien endometriosis yang menjalani operasi dari November 2024 hingga April 2025. Ekspresi mRNA NGF diukur pada plasma darah dan jaringan ektopik. Riwayat nyeri dinilai secara retrospektif, dan stadium penyakit ditentukan secara intraoperatif. Hasil: Tidak ditemukan hubungan yang signifikan antara ekspresi mRNA NGF dengan tingkat nyeri maupun keparahan endometriosis baik pada plasma maupun jaringan lesi. Berdasarkan analisis metode Livak, nilai rata-rata ekspresi relatif mRNA gen NGF meningkat 6,943 kali lipat pada plasma darah dan 17,319 kali lipat pada lesi endometriosis pada wanita dengan endometriosis. Dalam uji Mann Whitney, terdapat perbedaan yang signifikan pada tingkat ekspresi mRNA gen NGF antara plasma darah dan jaringan lesi dengan p < 0,0001. Ekspresi NGF mungkin tidak selalu berkorelasi dengan keparahan penyakit karena dipengaruhi oleh banyak faktor. Kesimpulan: Tidak ditemukan korelasi signifikan antara ekspresi mRNA NGF dengan tingkat keparahan endometriosis atau intensitas nyeri, namun terdapat perbedaan signifikan antara tingkat ekspresi di plasma darah dan jaringan lesi. Kata Kunci: Endometriosis, Nyeri, Nerve Growth Factor (NGF), Ekspresi mRNA

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Endometriosis, Nyeri, Nerve Growth Factor (NGF), Ekspresi mRNA
Subjects:	R Medicine > RG Gynecology and obstetrics > RG1-991 Gynecology and obstetrics
Divisions:	04-Faculty of Medicine > 11708-Obstetric and Gynecology (Sp
Depositing User:	Bertha Octarina
Date Deposited:	15 May 2025 07:55
Last Modified:	15 May 2025 07:55
URI:	http://repository.unsri.ac.id/id/eprint/172416

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