HUBUNGAN KADAR VITAMIN D DAN NEUTROFIL LIMFOSIT RASIO (NLR) TERHADAP SKOR SLE DISEASE ACTIVITY INDEX (SLEDAI) PADA ANAK DENGAN LUPUS ERITEMATOSUS SISTEMIK DI RS. MOHAMMAD HOESIN PALEMBANG

PRATAMA, WINDA HARYATI and Alia, Myrna and Novery, Edy and Indrayady, Indrayady (2025) HUBUNGAN KADAR VITAMIN D DAN NEUTROFIL LIMFOSIT RASIO (NLR) TERHADAP SKOR SLE DISEASE ACTIVITY INDEX (SLEDAI) PADA ANAK DENGAN LUPUS ERITEMATOSUS SISTEMIK DI RS. MOHAMMAD HOESIN PALEMBANG. Other thesis, Sriwijaya University.

	Image RAMA_11711_04022722125004_COVER.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (89kB)
	Text RAMA_11711_04022722125004.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_11711_04022722125004_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (13MB) | Request a copy
	Text RAMA_11711_04022722125004_8858520016_8834220016_8883220016_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (1MB)
	Text RAMA_11711_04022722125004_8858520016_8834220016_8883220016_02.pdf Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (945kB) | Request a copy
	Text RAMA_11711_04022722125004_8858520016_8834220016_8883220016_03.pdf Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (276kB) | Request a copy
	Text RAMA_11711_04022722125004_8858520016_8834220016_8883220016_04.pdf Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (230kB) | Request a copy
	Text RAMA_11711_04022722125004_8858520016_8834220016_8883220016_05.pdf Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (191kB) | Request a copy
	Text RAMA_11711_04022722125004_8858520016_8834220016_8883220016_06.pdf Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (105kB) | Request a copy
	Text RAMA_11711_04022722125004_8858520016_8834220016_8883220016_06_refpdf.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (204kB) | Request a copy
	Text RAMA_11711_04022722125004_8858520016_8834220016_8883220016_07_lamp_ref.pdf Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (691kB) | Request a copy

Abstract

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease affecting multiple organ systems. Incidence of children SLE increased by 15–17%, and outcomes are generally poorer compared to adults. Vitamin D plays an essen-tial role in immune regulation, and its deficiency may contribute to immune dysregulation in SLE. The Neutrophil-to-Lymphocyte Ratio (NLR) is a simple he-matological marker associated with systemic inflammation and disease activity in SLE. We aimed to evaluate the correlation between vitamin D levels, NLR, and disease activity measured by the SLE Disease Activity Index (SLEDAI) in children with SLE. Methods: A retrospective review of medical records was conducted for newly diagnosed pediatric SLE patients from January 2020 to December 2024. Results: Total of 144 children were included, with 97.2% aged over 10 years and 91.7% being female. Most patients had involvement of more than two organ sys-tems (85.4%) and infection comorbidities (39.6%). At diagnosis, 84% had high SLEDAI scores, 60.4% had vitamin D deficiency, and 53.6% had elevated NLR (≥3). The mean vitamin D level was 17.4 ± 5.3 ng/mL, and the average NLR was 3.3. Strong positive correlation was found between NLR and SLEDAI score (r = 0.89, p = 0.03). However, there was no significant correlation between vitamin D levels and either SLEDAI scores (r = 0.35, p = 0.21) or NLR (r = 0.17, p = 0.12). Conclusion: NLR is significantly correlated with disease activity in pediatric SLE, whereas vitamin D levels show no significant relationship with disease activity or NLR.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	Systemic Lupus Erythematosus, anak, Vitamin D, NLR ratio, skor SLEDAI
Subjects:	R Medicine > RJ Pediatrics > RJ1-570 Pediatrics
Divisions:	04-Faculty of Medicine > 11711-Pediatrics (Sp
Depositing User:	WINDA HARYATI PRATAMA
Date Deposited:	21 May 2025 01:50
Last Modified:	21 May 2025 01:50
URI:	http://repository.unsri.ac.id/id/eprint/173093

Actions (login required)

View Item