EFEKTIVITAS INJEKSI PLATELET RICH PLASMA PERINEURAL PADA N. TIBIALIS POSTERIOR TERHADAP SKALA NYERI PENDERITA NYERI NEUROPATI DIABETIK DI RS DR. MOHAMMAD HOESIN PALEMBANG

RAHMA, FITHRY and Sugiharto, Henry and Christin, Theresia and Irsan Saleh, Mgs (2025) EFEKTIVITAS INJEKSI PLATELET RICH PLASMA PERINEURAL PADA N. TIBIALIS POSTERIOR TERHADAP SKALA NYERI PENDERITA NYERI NEUROPATI DIABETIK DI RS DR. MOHAMMAD HOESIN PALEMBANG. Masters thesis, Sriwijaya University.

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Abstract

Background: Diabetic neuropathic pain (DNP) is a chronic and painful complication of diabetes mellitus that is often difficult to treat. Perineural platelet-rich plasma (PRP) injection has the potential to enhance vascular endothelial growth factor, tissue remodeling, and axonal nerve regeneration.Objective: To evaluate the effectiveness of perineural PRP injection in reducing pain and neuropathy severity in DNP patients at Dr. Mohammad Hoesin Hospital Palembang.Methods: A single-blind, add-on randomized controlled trial (RCT) involving 30 subjects divided into PRP and placebo (0.9% NaCl) groups. Assessments were conducted at weeks 0, 2, 4, 6, and 8 using the Numeric Pain Rating Scale (NPRS) and Toronto Clinical Neuropathy Score (TCNS).Results: The PRP group showed a significant NPRS reduction from 7.26 ± 1.75 to 3.73 ± 1.86 (p < 0.001), while the placebo group decreased from 7 (3–9) to 5 (3–8) (p = 0.027). PRP had a greater effect on NPRS reduction (48.6%) with significant differences at weeks 4 (p = 0.029), 6 (p = 0.005), and 8 (p = 0.010). TCNS decreased significantly in both groups (PRP: p < 0.001; placebo: p = 0.003), but no weekly difference was found between groups.Conclusion: Perineural PRP injection is effective in reducing moderate to severe pain intensity but not effective in improving neuropathy grade. Keywords: Diabetic neuropathic pain, diabetic neuropathy, platelet rich plasma, tibial posterior nerve.

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	Diabetic neuropathic pain, diabetic neuropathy, platelet rich plasma, tibial posterior nerve.
Subjects:	R Medicine > RC Internal medicine > RC346-429 Neurology. Diseases of the nervous system. Including speech disorders
Divisions:	04-Faculty of Medicine > 11703-Neurology (Sp
Depositing User:	Fithry Rahma
Date Deposited:	23 May 2025 04:47
Last Modified:	23 May 2025 04:47
URI:	http://repository.unsri.ac.id/id/eprint/173720

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