HUBUNGAN KADAR VITAMIN D DENGAN JENIS OBAT ANTI EPILEPSI PADA PENDERITA EPILEPSI DI INSTALASI RAWAT JALAN RS MOHAMMAD HOESIN PALEMBANG

ANANTA AVIS, CITRA and Handayani, Sri and Hafy, Zen (2025) HUBUNGAN KADAR VITAMIN D DENGAN JENIS OBAT ANTI EPILEPSI PADA PENDERITA EPILEPSI DI INSTALASI RAWAT JALAN RS MOHAMMAD HOESIN PALEMBANG. Masters thesis, Sriwijaya University.

Preview	Image RAMA_11703_04072782125003_cover.jpeg - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (1MB) | Preview
	Text RAMA_11703_04072782125003.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_11703_04072782125003_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (19MB) | Request a copy
	Text RAMA_11703_04072782125003_8899311019_0029127201_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (1MB)
	Text RAMA_11703_04072782125003_8899311019_0029127201_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_11703_04072782125003_8899311019_0029127201_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (854kB) | Request a copy
	Text RAMA_11703_04072782125003_8899311019_0029127201_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (696kB) | Request a copy
	Text RAMA_11703_04072782125003_8899311019_0029127201_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (647kB) | Request a copy
	Text RAMA_11703_04072782125003_8899311019_0029127201_06.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (691kB) | Request a copy
	Text RAMA_11703_04072782125003_8899311019_0029127201_07_ref.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (474kB) | Request a copy
	Text RAMA_11703_04072782125003_8899311019_0029127201_08_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy

Abstract

Background: Epilepsy is a disease characterized by recurrent seizure caused by altered brain electrical activity. Anti-epileptic drugs (AEDs) are recognized to induce vitamin D catabolism, especially CYP450 enzyme inducer-type AED. Several studies have shown that patients taking enzyme inducer-type AEDs have significantly lower vitamin D levels Method: This study was an analytical cross-sectional study using secondary data from medical records of epilepsy patients who were treated at the Outpatient Department of Mohammad Hoesin Hospital, Palembang from September 1, 2023 to August 31, 2024. Data were analyzed using univariate and bivariate analysis with the Chi Square test to evaluate the relationship between type of AED and vitamin D levels. Result: From 60 patients, 81.7% of them having vitamin D levels <30 ng/dL. There was a significant relationship between the type of AED and vitamin D levels (p value=0.000). Patients consumed enzyme inducer AEDs had 17.55-fold increased chance of having vitamin D levels <30 ng/dL (OR=17.55). Conclusion: Enzyme inducer-type of AEDs significantly increases the risk of epilepsy patients having vitamin D levels <30 ng/dL. This study emphasizes the importance of routine clinical evaluation to monitor changes in vitamin D levels and the importance of vitamin D supplementation in epilepsy patients consumed AEDs, especially enzyme inducer. Keywords: anti epileptic drug, vitamin D level, epilepsy.

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	anti epileptic drug, vitamin D level, epilepsy.
Subjects:	R Medicine > RC Internal medicine > RC346-429 Neurology. Diseases of the nervous system. Including speech disorders
Divisions:	04-Faculty of Medicine > 11703-Neurology (Sp
Depositing User:	Citra Ananta Avis
Date Deposited:	23 May 2025 06:17
Last Modified:	23 May 2025 06:17
URI:	http://repository.unsri.ac.id/id/eprint/173893

Actions (login required)

View Item