PREPARASI DAN KARAKTERISASI PARTIKEL POLY LACTIC CO-GLYCOLIC ACID PEMBAWA KLINDAMISIN DENGAN POLY VINYL ALCOHOL SEBAGAI STABILIZER

ARDIAN, MUHAMMAD RAEDI and Mardiyanto, Mardiyanto and Untari, Budi (2017) PREPARASI DAN KARAKTERISASI PARTIKEL POLY LACTIC CO-GLYCOLIC ACID PEMBAWA KLINDAMISIN DENGAN POLY VINYL ALCOHOL SEBAGAI STABILIZER. Undergraduate thesis, Sriwijaya University.

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Abstract

Propionibacterium acne (P. acne) is a group of bacteria that causes acne. P. acne lived by consuming chemical compounds from sweat glands and fat on the skin face. Fluids in acne containspus, red blood cell lysis component and cytokine which is produced by cell’s of body defences. P. acne bacteria hides in that fluids and can proliferate. Most of free molecule of clindamycin can not reach P. acne. However, submicro particles can reach that because the particles are protected by PLGA and PVA, so that it can minimize the damage caused by acne fluids. In this research, there were three formulas which are distinguished by the differences amount of PVA (stabilizer) 40 mg for F1, 50 mg for F2 and 60 mg for F3. The percentages of encapsulation efficiency was measured by using spectrophotometry UV-Visible. F2 with 50 mg of PVA showed the highest value of %EE that is 96,856 ± 0,160%. F3 with 60 mg of PVA showed the lowest value of %EE that is 94,853 ± 0,289%. F1 with 40 mg PVA showed the lowest %EE. The highest value of %EE F2 indicated that more clindamycin are encapsulated in F2. The result of particle characterization using dynamic light scatering (DLS) for F2 showed that uniformity of particles is 62% with particle size 428,9 ± 468,47 nm and the PDF value is 0,38. Result of F2 zeta potential measurements is -6,0 mV, it shows that particles of F2 are unstable. Characterization using transmission electron microscopy (TEM) of F2 showed spheric shape particle. The result of statistical parametric analysis one-way ANNOVA, post hoc tukey and LSD showed that PVA affected %EE of formulas with p value <0,05.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Clindamycin, Particles, PVA, PLGA
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 20 Nov 2019 08:40
Last Modified: 20 Nov 2019 08:40
URI: http://repository.unsri.ac.id/id/eprint/17403

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