STANDARDISASI DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK RANTING TUMBUHAN SIRSAK (Annona muricata Linn.) TERHADAP Escherichia coli dan Staphylococcus aureus

PRATIWI, SEPTALIA and Herlina, Herlina and Solihah, Indah (2016) STANDARDISASI DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK RANTING TUMBUHAN SIRSAK (Annona muricata Linn.) TERHADAP Escherichia coli dan Staphylococcus aureus. Undergraduate thesis, Sriwijaya University.

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Abstract

Traditionally, soursop plant widely used as a medicine to treat diarrhea and infections of the skin. Phytochemicals screening result indicates that the twigs of soursop positively contain alkaloids, tannins, flavonoids and saponins. This study was conducted to determine the antibacterial activity of soursop twigs extract concentrations of 5, 10, and 15% of the minimum inhibitory concentration (MIC) against Escherichia coli and Staphylococcus aureus after macerated with a solvent n-hexane, ethyl acetate, and 96% ethanol on solvents also to determine the standardization parameter value of the extract. This study is using agar diffusion method with paper discs for testing antibacterial activity. Extract with the smallest MIC was selected to be standardized. The standardization test includes specific and non-specific parameter. The minimum inhibitory concentration (MIC) of ethanol and ethyl acetate extract i.e 2% and 5%. The result of the standardization of ethanol extract through a specific parameter test showed that the extract thick,brownish-black, typical smell, and the taste slightly bitter. Content of extract soluble in water of 4.70% ± 1.53% and content of extract soluble in ethanol of 36.61% ± 5.74%. Meanwhile, the result through a non-specific parameter test of ethanol showed that the total ash content of 6.16% ± 1.60%, ash content insoluble in acid 1% ± 12%, drying shrink age of 34.95% ± 1.37%, and a specific gravity of 0.93 ± 0%.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Annona muricata Linn., Antibacterial, standardization.
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions: Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Mrs Dies Meirita Sari
Date Deposited: 20 Nov 2019 09:17
Last Modified: 20 Nov 2019 09:17
URI: http://repository.unsri.ac.id/id/eprint/17415

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